Haptoglobin and Its Related Protein, Zonulin—What Is Their Role in Spondyloarthropathy?

Haptoglobin (Hp) is an acute phase protein which supports the immune response and protects tissues from free radicals. Its concentration correlates with disease activity in spondyloarthropathies (SpAs). The Hp polymorphism determines the functional differences between Hp1 and Hp2 protein products. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Chmielińska, Magdalena, Olesińska, Marzena, Romanowska-Próchnicka, Katarzyna, Szukiewicz, Dariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962838/
https://www.ncbi.nlm.nih.gov/pubmed/33800376
http://dx.doi.org/10.3390/jcm10051131
Descripción
Sumario:Haptoglobin (Hp) is an acute phase protein which supports the immune response and protects tissues from free radicals. Its concentration correlates with disease activity in spondyloarthropathies (SpAs). The Hp polymorphism determines the functional differences between Hp1 and Hp2 protein products. The role of the Hp polymorphism has been demonstrated in many diseases. In particular, the Hp 2-2 phenotype has been associated with the unfavorable course of some inflammatory and autoimmune disorders. Its potential role in modulating the immune system in SpA is still unknown. This article contains pathophysiological considerations on the potential relationship between Hp, its polymorphism and SpA.

Ejemplares similares