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Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation

Ischemia reperfusion injury (IRI) is inevitable in kidney transplantation and negatively impacts graft and patient outcome. Reperfusion takes place in the recipient and most of the injury following ischemia and reperfusion occurs during this reperfusion phase; therefore, the intra-operative period s...

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Autores principales: Nieuwenhuijs-Moeke, Gertrude J., Bosch, Dirk J., Leuvenink, Henri G.D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962839/
https://www.ncbi.nlm.nih.gov/pubmed/33800423
http://dx.doi.org/10.3390/ijms22052727
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author Nieuwenhuijs-Moeke, Gertrude J.
Bosch, Dirk J.
Leuvenink, Henri G.D.
author_facet Nieuwenhuijs-Moeke, Gertrude J.
Bosch, Dirk J.
Leuvenink, Henri G.D.
author_sort Nieuwenhuijs-Moeke, Gertrude J.
collection PubMed
description Ischemia reperfusion injury (IRI) is inevitable in kidney transplantation and negatively impacts graft and patient outcome. Reperfusion takes place in the recipient and most of the injury following ischemia and reperfusion occurs during this reperfusion phase; therefore, the intra-operative period seems an attractive window of opportunity to modulate IRI and improve short- and potentially long-term graft outcome. Commonly used volatile anesthetics such as sevoflurane and isoflurane have been shown to interfere with many of the pathophysiological processes involved in the injurious cascade of IRI. Therefore, volatile anesthetic (VA) agents might be the preferred anesthetics used during the transplantation procedure. This review highlights the molecular and cellular protective points of engagement of VA shown in in vitro studies and in vivo animal experiments, and the potential translation of these results to the clinical setting of kidney transplantation.
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spelling pubmed-79628392021-03-17 Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation Nieuwenhuijs-Moeke, Gertrude J. Bosch, Dirk J. Leuvenink, Henri G.D. Int J Mol Sci Review Ischemia reperfusion injury (IRI) is inevitable in kidney transplantation and negatively impacts graft and patient outcome. Reperfusion takes place in the recipient and most of the injury following ischemia and reperfusion occurs during this reperfusion phase; therefore, the intra-operative period seems an attractive window of opportunity to modulate IRI and improve short- and potentially long-term graft outcome. Commonly used volatile anesthetics such as sevoflurane and isoflurane have been shown to interfere with many of the pathophysiological processes involved in the injurious cascade of IRI. Therefore, volatile anesthetic (VA) agents might be the preferred anesthetics used during the transplantation procedure. This review highlights the molecular and cellular protective points of engagement of VA shown in in vitro studies and in vivo animal experiments, and the potential translation of these results to the clinical setting of kidney transplantation. MDPI 2021-03-08 /pmc/articles/PMC7962839/ /pubmed/33800423 http://dx.doi.org/10.3390/ijms22052727 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nieuwenhuijs-Moeke, Gertrude J.
Bosch, Dirk J.
Leuvenink, Henri G.D.
Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation
title Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation
title_full Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation
title_fullStr Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation
title_full_unstemmed Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation
title_short Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation
title_sort molecular aspects of volatile anesthetic-induced organ protection and its potential in kidney transplantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962839/
https://www.ncbi.nlm.nih.gov/pubmed/33800423
http://dx.doi.org/10.3390/ijms22052727
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