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Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern

Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, there has been international concern about the emergence of virus variants with mutations that increase transmissibility, enhance escape from the human immune response, or otherwise alter biologically i...

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Autores principales: Long, S. Wesley, Olsen, Randall J., Christensen, Paul A., Subedi, Sishir, Olson, Robert, Davis, James J., Saavedra, Matthew Ojeda, Yerramilli, Prasanti, Pruitt, Layne, Reppond, Kristina, Shyer, Madison N., Cambric, Jessica, Finkelstein, Ilya J., Gollihar, Jimmy, Musser, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Investigative Pathology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962948/
https://www.ncbi.nlm.nih.gov/pubmed/33741335
http://dx.doi.org/10.1016/j.ajpath.2021.03.004
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author Long, S. Wesley
Olsen, Randall J.
Christensen, Paul A.
Subedi, Sishir
Olson, Robert
Davis, James J.
Saavedra, Matthew Ojeda
Yerramilli, Prasanti
Pruitt, Layne
Reppond, Kristina
Shyer, Madison N.
Cambric, Jessica
Finkelstein, Ilya J.
Gollihar, Jimmy
Musser, James M.
author_facet Long, S. Wesley
Olsen, Randall J.
Christensen, Paul A.
Subedi, Sishir
Olson, Robert
Davis, James J.
Saavedra, Matthew Ojeda
Yerramilli, Prasanti
Pruitt, Layne
Reppond, Kristina
Shyer, Madison N.
Cambric, Jessica
Finkelstein, Ilya J.
Gollihar, Jimmy
Musser, James M.
author_sort Long, S. Wesley
collection PubMed
description Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, there has been international concern about the emergence of virus variants with mutations that increase transmissibility, enhance escape from the human immune response, or otherwise alter biologically important phenotypes. In late 2020, several variants of concern emerged globally, including the UK variant (B.1.1.7), the South Africa variant (B.1.351), Brazil variants (P.1 and P.2), and two related California variants of interest (B.1.429 and B.1.427). These variants are believed to have enhanced transmissibility. For the South Africa and Brazil variants, there is evidence that mutations in spike protein permit it to escape from some vaccines and therapeutic monoclonal antibodies. On the basis of our extensive genome sequencing program involving 20,453 coronavirus disease 2019 patient samples collected from March 2020 to February 2021, we report identification of all six of these SARS-CoV-2 variants among Houston Methodist Hospital (Houston, TX) patients residing in the greater metropolitan area. Although these variants are currently at relatively low frequency (aggregate of 1.1%) in the population, they are geographically widespread. Houston is the first city in the United States in which active circulation of all six current variants of concern has been documented by genome sequencing. As vaccine deployment accelerates, increased genomic surveillance of SARS-CoV-2 is essential to understanding the presence, frequency, and medical impact of consequential variants and their patterns and trajectory of dissemination.
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spelling pubmed-79629482021-03-17 Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern Long, S. Wesley Olsen, Randall J. Christensen, Paul A. Subedi, Sishir Olson, Robert Davis, James J. Saavedra, Matthew Ojeda Yerramilli, Prasanti Pruitt, Layne Reppond, Kristina Shyer, Madison N. Cambric, Jessica Finkelstein, Ilya J. Gollihar, Jimmy Musser, James M. Am J Pathol Short Communication Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, there has been international concern about the emergence of virus variants with mutations that increase transmissibility, enhance escape from the human immune response, or otherwise alter biologically important phenotypes. In late 2020, several variants of concern emerged globally, including the UK variant (B.1.1.7), the South Africa variant (B.1.351), Brazil variants (P.1 and P.2), and two related California variants of interest (B.1.429 and B.1.427). These variants are believed to have enhanced transmissibility. For the South Africa and Brazil variants, there is evidence that mutations in spike protein permit it to escape from some vaccines and therapeutic monoclonal antibodies. On the basis of our extensive genome sequencing program involving 20,453 coronavirus disease 2019 patient samples collected from March 2020 to February 2021, we report identification of all six of these SARS-CoV-2 variants among Houston Methodist Hospital (Houston, TX) patients residing in the greater metropolitan area. Although these variants are currently at relatively low frequency (aggregate of 1.1%) in the population, they are geographically widespread. Houston is the first city in the United States in which active circulation of all six current variants of concern has been documented by genome sequencing. As vaccine deployment accelerates, increased genomic surveillance of SARS-CoV-2 is essential to understanding the presence, frequency, and medical impact of consequential variants and their patterns and trajectory of dissemination. American Society for Investigative Pathology 2021-06 /pmc/articles/PMC7962948/ /pubmed/33741335 http://dx.doi.org/10.1016/j.ajpath.2021.03.004 Text en © 2021 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.
spellingShingle Short Communication
Long, S. Wesley
Olsen, Randall J.
Christensen, Paul A.
Subedi, Sishir
Olson, Robert
Davis, James J.
Saavedra, Matthew Ojeda
Yerramilli, Prasanti
Pruitt, Layne
Reppond, Kristina
Shyer, Madison N.
Cambric, Jessica
Finkelstein, Ilya J.
Gollihar, Jimmy
Musser, James M.
Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern
title Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern
title_full Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern
title_fullStr Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern
title_full_unstemmed Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern
title_short Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern
title_sort sequence analysis of 20,453 severe acute respiratory syndrome coronavirus 2 genomes from the houston metropolitan area identifies the emergence and widespread distribution of multiple isolates of all major variants of concern
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962948/
https://www.ncbi.nlm.nih.gov/pubmed/33741335
http://dx.doi.org/10.1016/j.ajpath.2021.03.004
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