Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review

Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID-19. A variety of antithrombotic agents, doses...

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Detalles Bibliográficos
Autores principales: Talasaz, Azita H., Sadeghipour, Parham, Kakavand, Hessam, Aghakouchakzadeh, Maryam, Kordzadeh-Kermani, Elaheh, Van Tassell, Benjamin W., Gheymati, Azin, Ariannejad, Hamid, Hosseini, Seyed Hossein, Jamalkhani, Sepehr, Sholzberg, Michelle, Monreal, Manuel, Jimenez, David, Piazza, Gregory, Parikh, Sahil A., Kirtane, Ajay J., Eikelboom, John W., Connors, Jean M., Hunt, Beverley J., Konstantinides, Stavros V., Cushman, Mary, Weitz, Jeffrey I., Stone, Gregg W., Krumholz, Harlan M., Lip, Gregory Y.H., Goldhaber, Samuel Z., Bikdeli, Behnood
Formato: Online Artículo Texto
Lenguaje:English
Publicado: by the American College of Cardiology Foundation. Published by Elsevier. 2021
Materias:
The Present and Future
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963001/
https://www.ncbi.nlm.nih.gov/pubmed/33741176
http://dx.doi.org/10.1016/j.jacc.2021.02.035
Descripción
Sumario:Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID-19. A variety of antithrombotic agents, doses, and durations of therapy are being assessed in ongoing randomized controlled trials (RCTs) that focus on outpatients, hospitalized patients in medical wards, and patients critically ill with COVID-19. This paper provides a perspective of the ongoing or completed RCTs related to antithrombotic strategies used in COVID-19, the opportunities and challenges for the clinical trial enterprise, and areas of existing knowledge, as well as data gaps that may motivate the design of future RCTs.

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