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MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation
Clinical data indicate that patients with C-reactive protein (CRP) levels higher than 2 mg per liter suffer from persistent inflammation, which is associated with high risk of cardiovascular disease (CVD). We determined whether a panel of biomarkers associated with CVD could predict recurrent events...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963189/ https://www.ncbi.nlm.nih.gov/pubmed/33803115 http://dx.doi.org/10.3390/jcm10051137 |
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author | Blanco-Colio, Luis M. Méndez-Barbero, Nerea Pello Lázaro, Ana María Aceña, Álvaro Tarín, Nieves Cristóbal, Carmen Martínez-Milla, Juan González-Lorenzo, Óscar Martín-Ventura, José Luis Huelmos, Ana Gutiérrez-Landaluce, Carlos López-Castillo, Marta Kallmeyer, Andrea Cánovas, Ester Alonso, Joaquín López Bescós, Lorenzo Egido, Jesús Lorenzo, Óscar Tuñón, José |
author_facet | Blanco-Colio, Luis M. Méndez-Barbero, Nerea Pello Lázaro, Ana María Aceña, Álvaro Tarín, Nieves Cristóbal, Carmen Martínez-Milla, Juan González-Lorenzo, Óscar Martín-Ventura, José Luis Huelmos, Ana Gutiérrez-Landaluce, Carlos López-Castillo, Marta Kallmeyer, Andrea Cánovas, Ester Alonso, Joaquín López Bescós, Lorenzo Egido, Jesús Lorenzo, Óscar Tuñón, José |
author_sort | Blanco-Colio, Luis M. |
collection | PubMed |
description | Clinical data indicate that patients with C-reactive protein (CRP) levels higher than 2 mg per liter suffer from persistent inflammation, which is associated with high risk of cardiovascular disease (CVD). We determined whether a panel of biomarkers associated with CVD could predict recurrent events in patients with low or persistent inflammation and coronary artery disease (CAD). We followed 917 patients with CAD (median 4.59 ± 2.39 years), assessing CRP, galectin-3, monocyte chemoattractant protein-1 (MCP-1), N-terminal fragment of brain natriuretic peptide (NT-proBNP) and troponin-I plasma levels. The primary outcome was the combination of cardiovascular events (acute coronary syndrome, stroke or transient ischemic event, heart failure or death). Patients with persistent inflammation (n = 343) showed higher NT-proBNP and MCP-1 plasma levels compared to patients with CRP < 2 mg/L. Neither MCP-1 nor NT-proBNP was associated with primary outcome in patients with CRP < 2 mg/L. However, NT-proBNP and MCP-1 plasma levels were associated with increased risk of the primary outcome in patients with persistent inflammation. When patients were divided by type of event, MCP-1 was associated with an increased risk of acute ischemic events. A significant interaction between MCP-1 and persistent inflammation was found (synergy index: 6.17 (4.39–7.95)). In conclusion, MCP-1 plasma concentration is associated with recurrent cardiovascular events in patients with persistent inflammation. |
format | Online Article Text |
id | pubmed-7963189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79631892021-03-17 MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation Blanco-Colio, Luis M. Méndez-Barbero, Nerea Pello Lázaro, Ana María Aceña, Álvaro Tarín, Nieves Cristóbal, Carmen Martínez-Milla, Juan González-Lorenzo, Óscar Martín-Ventura, José Luis Huelmos, Ana Gutiérrez-Landaluce, Carlos López-Castillo, Marta Kallmeyer, Andrea Cánovas, Ester Alonso, Joaquín López Bescós, Lorenzo Egido, Jesús Lorenzo, Óscar Tuñón, José J Clin Med Article Clinical data indicate that patients with C-reactive protein (CRP) levels higher than 2 mg per liter suffer from persistent inflammation, which is associated with high risk of cardiovascular disease (CVD). We determined whether a panel of biomarkers associated with CVD could predict recurrent events in patients with low or persistent inflammation and coronary artery disease (CAD). We followed 917 patients with CAD (median 4.59 ± 2.39 years), assessing CRP, galectin-3, monocyte chemoattractant protein-1 (MCP-1), N-terminal fragment of brain natriuretic peptide (NT-proBNP) and troponin-I plasma levels. The primary outcome was the combination of cardiovascular events (acute coronary syndrome, stroke or transient ischemic event, heart failure or death). Patients with persistent inflammation (n = 343) showed higher NT-proBNP and MCP-1 plasma levels compared to patients with CRP < 2 mg/L. Neither MCP-1 nor NT-proBNP was associated with primary outcome in patients with CRP < 2 mg/L. However, NT-proBNP and MCP-1 plasma levels were associated with increased risk of the primary outcome in patients with persistent inflammation. When patients were divided by type of event, MCP-1 was associated with an increased risk of acute ischemic events. A significant interaction between MCP-1 and persistent inflammation was found (synergy index: 6.17 (4.39–7.95)). In conclusion, MCP-1 plasma concentration is associated with recurrent cardiovascular events in patients with persistent inflammation. MDPI 2021-03-09 /pmc/articles/PMC7963189/ /pubmed/33803115 http://dx.doi.org/10.3390/jcm10051137 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Blanco-Colio, Luis M. Méndez-Barbero, Nerea Pello Lázaro, Ana María Aceña, Álvaro Tarín, Nieves Cristóbal, Carmen Martínez-Milla, Juan González-Lorenzo, Óscar Martín-Ventura, José Luis Huelmos, Ana Gutiérrez-Landaluce, Carlos López-Castillo, Marta Kallmeyer, Andrea Cánovas, Ester Alonso, Joaquín López Bescós, Lorenzo Egido, Jesús Lorenzo, Óscar Tuñón, José MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation |
title | MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation |
title_full | MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation |
title_fullStr | MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation |
title_full_unstemmed | MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation |
title_short | MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation |
title_sort | mcp-1 predicts recurrent cardiovascular events in patients with persistent inflammation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963189/ https://www.ncbi.nlm.nih.gov/pubmed/33803115 http://dx.doi.org/10.3390/jcm10051137 |
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