Mitochondrial Mistranslation in Brain Provokes a Metabolic Response Which Mitigates the Age-Associated Decline in Mitochondrial Gene Expression

Mitochondrial misreading, conferred by mutation V338Y in mitoribosomal protein Mrps5, in-vivo is associated with a subtle neurological phenotype. Brain mitochondria of homozygous knock-in mutant Mrps5(V338Y/V338Y) mice show decreased oxygen consumption and reduced ATP levels. Using a combination of...

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Detalles Bibliográficos
Autores principales: Shcherbakov, Dimitri, Juskeviciene, Reda, Cortés Sanchón, Adrián, Brilkova, Margarita, Rehrauer, Hubert, Laczko, Endre, Böttger, Erik C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963198/
https://www.ncbi.nlm.nih.gov/pubmed/33803109
http://dx.doi.org/10.3390/ijms22052746

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