Inhibition of longevity regulator PAPP‐A modulates tissue homeostasis via restraint of mesenchymal stromal cells

Pregnancy‐associated plasma protein‐A (PAPP‐A) is a secreted metalloprotease that increases insulin‐like growth factor (IGF) availability by cleaving IGF‐binding proteins. Reduced IGF signaling extends longevity in multiple species, and consistent with this, PAPP‐A deletion extends lifespan and heal...

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Detalles Bibliográficos
Autores principales: Mohrin, Mary, Liu, Justin, Zavala‐Solorio, Jose, Bhargava, Sakshi, Maxwell Trumble, John, Brito, Alyssa, Hu, Dorothy, Brooks, Daniel, Koukos, Georgios, Alabdulaaly, Lama, Paw, Jonathan S., Hake, Kayley, Kolumam, Ganesh, Bouxsein, Mary L., Baron, Roland, Kutskova, Yuliya, Freund, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963332/
https://www.ncbi.nlm.nih.gov/pubmed/33561324
http://dx.doi.org/10.1111/acel.13313

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