Nipping Adipocyte Inflammation in the Bud

Adipose tissue inflammation continues to represent a significant area of research in immunometabolism. We have identified a transcription factor, EBF1, which crucially regulates the expression of numerous inflammatory loci in adipocytes. However, EBF1 appears to do so without physically binding to t...

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Detalles Bibliográficos
Autor principal: Griffin, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963359/
https://www.ncbi.nlm.nih.gov/pubmed/33732506
http://dx.doi.org/10.20900/immunometab20210012
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author Griffin, Michael J.
author_facet Griffin, Michael J.
author_sort Griffin, Michael J.
collection PubMed
description Adipose tissue inflammation continues to represent a significant area of research in immunometabolism. We have identified a transcription factor, EBF1, which crucially regulates the expression of numerous inflammatory loci in adipocytes. However, EBF1 appears to do so without physically binding to these inflammatory genes. Our research is currently focused on understanding this discrepancy, and we believe that future findings could pave the road for drug development aimed to block adipose inflammation at its source.
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spelling pubmed-79633592021-03-16 Nipping Adipocyte Inflammation in the Bud Griffin, Michael J. Immunometabolism Article Adipose tissue inflammation continues to represent a significant area of research in immunometabolism. We have identified a transcription factor, EBF1, which crucially regulates the expression of numerous inflammatory loci in adipocytes. However, EBF1 appears to do so without physically binding to these inflammatory genes. Our research is currently focused on understanding this discrepancy, and we believe that future findings could pave the road for drug development aimed to block adipose inflammation at its source. 2021-02-14 2021 /pmc/articles/PMC7963359/ /pubmed/33732506 http://dx.doi.org/10.20900/immunometab20210012 Text en Open Access Licensee Hapres, London, United Kingdom. This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Griffin, Michael J.
Nipping Adipocyte Inflammation in the Bud
title Nipping Adipocyte Inflammation in the Bud
title_full Nipping Adipocyte Inflammation in the Bud
title_fullStr Nipping Adipocyte Inflammation in the Bud
title_full_unstemmed Nipping Adipocyte Inflammation in the Bud
title_short Nipping Adipocyte Inflammation in the Bud
title_sort nipping adipocyte inflammation in the bud
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963359/
https://www.ncbi.nlm.nih.gov/pubmed/33732506
http://dx.doi.org/10.20900/immunometab20210012
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