Macrophages Fuel Skeletal Muscle Regeneration

In this commentary we discuss new findings presented by Shang et al. regarding the role of macrophage-derived glutamine in skeletal muscle repair. Loss-of-function of glutamate dehydrogenase in macrophages led to an upregulation of glutamine synthesis which sustained glutamine levels in muscle tissu...

Descripción completa

Detalles Bibliográficos
Autor principal: Schilling, Joel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963361/
https://www.ncbi.nlm.nih.gov/pubmed/33732507
http://dx.doi.org/10.20900/immunometab20210013
_version_ 1783665595246444544
author Schilling, Joel D.
author_facet Schilling, Joel D.
author_sort Schilling, Joel D.
collection PubMed
description In this commentary we discuss new findings presented by Shang et al. regarding the role of macrophage-derived glutamine in skeletal muscle repair. Loss-of-function of glutamate dehydrogenase in macrophages led to an upregulation of glutamine synthesis which sustained glutamine levels in muscle tissue and facilitated satellite cell proliferation and differentiation.
format Online
Article
Text
id pubmed-7963361
institution National Center for Biotechnology Information
language English
publishDate 2021
record_format MEDLINE/PubMed
spelling pubmed-79633612021-03-16 Macrophages Fuel Skeletal Muscle Regeneration Schilling, Joel D. Immunometabolism Article In this commentary we discuss new findings presented by Shang et al. regarding the role of macrophage-derived glutamine in skeletal muscle repair. Loss-of-function of glutamate dehydrogenase in macrophages led to an upregulation of glutamine synthesis which sustained glutamine levels in muscle tissue and facilitated satellite cell proliferation and differentiation. 2021-02-19 2021 /pmc/articles/PMC7963361/ /pubmed/33732507 http://dx.doi.org/10.20900/immunometab20210013 Text en This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Schilling, Joel D.
Macrophages Fuel Skeletal Muscle Regeneration
title Macrophages Fuel Skeletal Muscle Regeneration
title_full Macrophages Fuel Skeletal Muscle Regeneration
title_fullStr Macrophages Fuel Skeletal Muscle Regeneration
title_full_unstemmed Macrophages Fuel Skeletal Muscle Regeneration
title_short Macrophages Fuel Skeletal Muscle Regeneration
title_sort macrophages fuel skeletal muscle regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963361/
https://www.ncbi.nlm.nih.gov/pubmed/33732507
http://dx.doi.org/10.20900/immunometab20210013
work_keys_str_mv AT schillingjoeld macrophagesfuelskeletalmuscleregeneration

Ejemplares similares