Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task

We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlati...

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Detalles Bibliográficos
Autores principales: Yang, Hongdian, Bari, Bilal A, Cohen, Jeremiah Y, O'Connor, Daniel H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963470/
https://www.ncbi.nlm.nih.gov/pubmed/33721552
http://dx.doi.org/10.7554/eLife.64327
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author Yang, Hongdian
Bari, Bilal A
Cohen, Jeremiah Y
O'Connor, Daniel H
author_facet Yang, Hongdian
Bari, Bilal A
Cohen, Jeremiah Y
O'Connor, Daniel H
author_sort Yang, Hongdian
collection PubMed
description We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1, and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity.
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spelling pubmed-79634702021-03-17 Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task Yang, Hongdian Bari, Bilal A Cohen, Jeremiah Y O'Connor, Daniel H eLife Neuroscience We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1, and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity. eLife Sciences Publications, Ltd 2021-03-15 /pmc/articles/PMC7963470/ /pubmed/33721552 http://dx.doi.org/10.7554/eLife.64327 Text en © 2021, Yang et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Yang, Hongdian
Bari, Bilal A
Cohen, Jeremiah Y
O'Connor, Daniel H
Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task
title Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task
title_full Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task
title_fullStr Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task
title_full_unstemmed Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task
title_short Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task
title_sort locus coeruleus spiking differently correlates with s1 cortex activity and pupil diameter in a tactile detection task
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963470/
https://www.ncbi.nlm.nih.gov/pubmed/33721552
http://dx.doi.org/10.7554/eLife.64327
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