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Integrative frontal-parietal dynamics supporting cognitive control
Coordinating among the demands of the external environment and internal plans requires cognitive control supported by a fronto-parietal control network (FPCN). Evidence suggests that multiple control systems span the FPCN whose operations are poorly understood. Previously (Nee and D’Esposito, 2016;...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963482/ https://www.ncbi.nlm.nih.gov/pubmed/33650966 http://dx.doi.org/10.7554/eLife.57244 |
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author | Nee, Derek Evan |
author_facet | Nee, Derek Evan |
author_sort | Nee, Derek Evan |
collection | PubMed |
description | Coordinating among the demands of the external environment and internal plans requires cognitive control supported by a fronto-parietal control network (FPCN). Evidence suggests that multiple control systems span the FPCN whose operations are poorly understood. Previously (Nee and D’Esposito, 2016; 2017), we detailed frontal dynamics that support control processing, but left open their role in broader cortical function. Here, I show that the FPCN consists of an external/present-oriented to internal/future-oriented cortical gradient extending outwardly from sensory-motor cortices. Areas at the ends of this gradient act in a segregative manner, exciting areas at the same level, but suppressing areas at different levels. By contrast, areas in the middle of the gradient excite areas at all levels, promoting integration of control processing. Individual differences in integrative dynamics predict higher level cognitive ability and amenability to neuromodulation. These data suggest that an intermediary zone within the FPCN underlies integrative processing that supports cognitive control. |
format | Online Article Text |
id | pubmed-7963482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-79634822021-03-17 Integrative frontal-parietal dynamics supporting cognitive control Nee, Derek Evan eLife Neuroscience Coordinating among the demands of the external environment and internal plans requires cognitive control supported by a fronto-parietal control network (FPCN). Evidence suggests that multiple control systems span the FPCN whose operations are poorly understood. Previously (Nee and D’Esposito, 2016; 2017), we detailed frontal dynamics that support control processing, but left open their role in broader cortical function. Here, I show that the FPCN consists of an external/present-oriented to internal/future-oriented cortical gradient extending outwardly from sensory-motor cortices. Areas at the ends of this gradient act in a segregative manner, exciting areas at the same level, but suppressing areas at different levels. By contrast, areas in the middle of the gradient excite areas at all levels, promoting integration of control processing. Individual differences in integrative dynamics predict higher level cognitive ability and amenability to neuromodulation. These data suggest that an intermediary zone within the FPCN underlies integrative processing that supports cognitive control. eLife Sciences Publications, Ltd 2021-03-02 /pmc/articles/PMC7963482/ /pubmed/33650966 http://dx.doi.org/10.7554/eLife.57244 Text en © 2021, Nee http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Nee, Derek Evan Integrative frontal-parietal dynamics supporting cognitive control |
title | Integrative frontal-parietal dynamics supporting cognitive control |
title_full | Integrative frontal-parietal dynamics supporting cognitive control |
title_fullStr | Integrative frontal-parietal dynamics supporting cognitive control |
title_full_unstemmed | Integrative frontal-parietal dynamics supporting cognitive control |
title_short | Integrative frontal-parietal dynamics supporting cognitive control |
title_sort | integrative frontal-parietal dynamics supporting cognitive control |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963482/ https://www.ncbi.nlm.nih.gov/pubmed/33650966 http://dx.doi.org/10.7554/eLife.57244 |
work_keys_str_mv | AT neederekevan integrativefrontalparietaldynamicssupportingcognitivecontrol |