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New threatening of SARS-CoV-2 coinfection and strategies to fight the current pandemic
Coronavirus disease (COVID-19) is a global pandemic. The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has overloaded healthcare systems that need medication to be rapidly established, at least to minimize the incidence of COVID-19. The coinfection with oth...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier B.V.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963520/ https://www.ncbi.nlm.nih.gov/pubmed/33748740 http://dx.doi.org/10.1016/j.medidd.2021.100089 |
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author | Goel, Nikky Ahmad, Razi Fatima, Huma Khare, Sunil Kumar |
author_facet | Goel, Nikky Ahmad, Razi Fatima, Huma Khare, Sunil Kumar |
author_sort | Goel, Nikky |
collection | PubMed |
description | Coronavirus disease (COVID-19) is a global pandemic. The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has overloaded healthcare systems that need medication to be rapidly established, at least to minimize the incidence of COVID-19. The coinfection with other microorganisms has drastically affected human health. Due to the utmost necessity to treat the patient infected with COVID-19 earliest, poor diagnosis and misuse of antibiotics may lead the world where no more drugs are available even to treat mild infections. Besides, sanitizers and disinfectants used to help minimize widespread coronavirus infection risk also contribute to an increased risk of antimicrobial resistance. To ease the situation, zinc supplements’ potentiality has been explored and found to be an effective element to boost the immune system. Zinc also prevents the entry of the virus by increasing the ciliary beat frequency. Furthermore, the limitations of current antiviral agents such as a narrow range and low bioavailability can be resolved using nanomaterials, which are considered an important therapeutic alternative for the next generation. Thus, the development of new antiviral nanoagents will significantly help tackle many potential challenges and knowledge gaps. This review paper provides profound insight into how COVID-19 and antimicrobial resistance (AMR) are interrelated and the possible implications and current strategies to fight the ongoing pandemic. |
format | Online Article Text |
id | pubmed-7963520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Author(s). Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79635202021-03-17 New threatening of SARS-CoV-2 coinfection and strategies to fight the current pandemic Goel, Nikky Ahmad, Razi Fatima, Huma Khare, Sunil Kumar Med Drug Discov Review Article Coronavirus disease (COVID-19) is a global pandemic. The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has overloaded healthcare systems that need medication to be rapidly established, at least to minimize the incidence of COVID-19. The coinfection with other microorganisms has drastically affected human health. Due to the utmost necessity to treat the patient infected with COVID-19 earliest, poor diagnosis and misuse of antibiotics may lead the world where no more drugs are available even to treat mild infections. Besides, sanitizers and disinfectants used to help minimize widespread coronavirus infection risk also contribute to an increased risk of antimicrobial resistance. To ease the situation, zinc supplements’ potentiality has been explored and found to be an effective element to boost the immune system. Zinc also prevents the entry of the virus by increasing the ciliary beat frequency. Furthermore, the limitations of current antiviral agents such as a narrow range and low bioavailability can be resolved using nanomaterials, which are considered an important therapeutic alternative for the next generation. Thus, the development of new antiviral nanoagents will significantly help tackle many potential challenges and knowledge gaps. This review paper provides profound insight into how COVID-19 and antimicrobial resistance (AMR) are interrelated and the possible implications and current strategies to fight the ongoing pandemic. The Author(s). Published by Elsevier B.V. 2021-06 2021-03-17 /pmc/articles/PMC7963520/ /pubmed/33748740 http://dx.doi.org/10.1016/j.medidd.2021.100089 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Article Goel, Nikky Ahmad, Razi Fatima, Huma Khare, Sunil Kumar New threatening of SARS-CoV-2 coinfection and strategies to fight the current pandemic |
title | New threatening of SARS-CoV-2 coinfection and strategies to fight the current pandemic |
title_full | New threatening of SARS-CoV-2 coinfection and strategies to fight the current pandemic |
title_fullStr | New threatening of SARS-CoV-2 coinfection and strategies to fight the current pandemic |
title_full_unstemmed | New threatening of SARS-CoV-2 coinfection and strategies to fight the current pandemic |
title_short | New threatening of SARS-CoV-2 coinfection and strategies to fight the current pandemic |
title_sort | new threatening of sars-cov-2 coinfection and strategies to fight the current pandemic |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963520/ https://www.ncbi.nlm.nih.gov/pubmed/33748740 http://dx.doi.org/10.1016/j.medidd.2021.100089 |
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