Cargando…

Differential activity and expression of human 5β-reductase (AKR1D1) splice variants

Steroid hormones, including glucocorticoids and androgens, exert a wide variety of effects in the body across almost all tissues. The steroid A-ring 5β-reductase (AKR1D1) is expressed in human liver and testes, and three splice variants have been identified (AKR1D1-001, AKR1D1-002, AKR1D1-006). Amon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Appanna, Nathan, Gibson, Hylton, Gangitano, Elena, Dempster, Niall J, Morris, Karen, George, Sherly, Arvaniti, Anastasia, Gathercole, Laura L, Keevil, Brian, Penning, Trevor M, Storbeck, Karl-Heinz, Tomlinson, Jeremy W, Nikolaou, Nikolaos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7965358/ https://www.ncbi.nlm.nih.gov/pubmed/33502336 http://dx.doi.org/10.1530/JME-20-0160

Ejemplares similares

Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo
por: Nikolaou, Nikolaos, et al.
Publicado: (2020)

AKR1D1 knockout mice develop a sex-dependent metabolic phenotype
por: Gathercole, Laura L, et al.
Publicado: (2022)

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease
por: Nikolaou, Nikolaos, et al.
Publicado: (2019)

Aldo-keto reductase (AKR) superfamily: Genomics and annotation
por: Mindnich, Rebekka D, et al.
Publicado: (2009)

Pleiotropic Actions of Aldehyde Reductase (AKR1A)
por: Fujii, Junichi, et al.
Publicado: (2021)

Aldo–Keto Reductase AKR1C1–AKR1C4: Functions, Regulation, and Intervention for Anti-cancer Therapy
por: Zeng, Chen-Ming, et al.
Publicado: (2017)

Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases
por: Rižner, Tea Lanišnik
Publicado: (2012)

MON-203 Local Activation of 11-Oxygenated Androgens by AKR1C3 Is the Predominant Source of Androgens in Human Female Adipose Tissue
por: Schiffer, Lina, et al.
Publicado: (2019)

(−)-Kusunokinin as a Potential Aldose Reductase Inhibitor: Equivalency Observed via AKR1B1 Dynamics Simulation
por: Tanawattanasuntorn, Tanotnon, et al.
Publicado: (2020)

New Insights into the Role of the Trypanosoma cruzi Aldo-Keto Reductase TcAKR
por: Díaz-Viraqué, Florencia, et al.
Publicado: (2023)

RF03 | PMON296 Insulin-induced AKR1C3 Metabolizes Classical and 11-oxygenated Androgens in a Model of PCOS Adipocytes
por: Mesaros, Clementina, et al.
Publicado: (2022)

Expression of the Aldo-Ketoreductases AKR1B1 and AKR1B10 in Human Cancers
por: Laffin, Brian, et al.
Publicado: (2012)

Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma
por: Zhu, Pengfei, et al.
Publicado: (2021)

AKR1B1 and AKR1B10 as Prognostic Biomarkers of Endometrioid Endometrial Carcinomas
por: Hojnik, Marko, et al.
Publicado: (2021)

Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma
por: Chung, Yeon Tae, et al.
Publicado: (2012)

Role of aldo‐keto reductase family 1 member B1 (AKR1B1) in the cancer process and its therapeutic potential
por: Khayami, Reza, et al.
Publicado: (2020)

Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema
por: Michelini, Sandro, et al.
Publicado: (2020)

The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions
por: Bresson, Eva, et al.
Publicado: (2012)

5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes
por: Nasiri, Maryam, et al.
Publicado: (2015)

Regulation Network and Prognostic Significance of Aldo-Keto Reductase (AKR) Superfamily Genes in Hepatocellular Carcinoma
por: Dai, Tianxing, et al.
Publicado: (2021)

In-silico Investigations of quinine and quinidine as potential Inhibitors of AKR1B1 and AKR1B10: Functional and structural characterization
por: Ejaz, Syeda Abida, et al.
Publicado: (2022)

AKR1B10 in gastrointestinal diseases
por: Shen, Yi, et al.
Publicado: (2015)

Roles of AKR1C3 in malignancy
por: Xiao, Xin-Zhu, et al.
Publicado: (2021)

Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line
por: Kljun, Jakob, et al.
Publicado: (2022)

Localization of an Aldo-Keto Reductase (AKR2E4) in the Silkworm Bombyx mori (Lepidoptera: Bombycidae)
por: Yamamoto, K, et al.
Publicado: (2017)

Comparison of Glyphosate-Degradation Ability of Aldo-Keto Reductase (AKR4) Proteins in Maize, Soybean and Rice
por: Chen, Ronghua, et al.
Publicado: (2023)

Methyl jasmonate enhances the radiation sensitivity of esophageal carcinoma cells by inhibiting the 11-ketoprostaglandin reductase activity of AKR1C3
por: Li, Xiaoying, et al.
Publicado: (2018)

Inhibitory selectivity to the AKR1B10 and aldose reductase (AR): insight from molecular dynamics simulations and free energy calculations
por: Lin, Ping, et al.
Publicado: (2023)

Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma
por: Lewis, Michael J, et al.
Publicado: (2004)

Transcript Levels of Aldo-Keto Reductase Family 1 Subfamily C (AKR1C) Are Increased in Prostate Tissue of Patients with Type 2 Diabetes
por: Franko, Andras, et al.
Publicado: (2020)

Modeling Single Nucleotide Polymorphisms in the Human AKR1C1 and AKR1C2 Genes: Implications for Functional and Genotyping Analyses
por: Arthur, Jonathan W., et al.
Publicado: (2010)

AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants
por: Ostinelli, Giada, et al.
Publicado: (2021)

AKR1C3 Converts Castrate and Post-Abiraterone DHEA-S into Testosterone to Stimulate Growth of Prostate Cancer Cells via 5-Androstene-3β,17β-Diol
por: Detlefsen, Andrea J., et al.
Publicado: (2023)

Expression of aldo-keto reductase family 1 member C1 (AKR1C1) gene in porcine ovary and uterine endometrium during the estrous cycle and pregnancy
por: Seo, Kyeong-Seok, et al.
Publicado: (2011)

AKR1C1-3, notably AKR1C3, are distinct biomarkers for liver cancer diagnosis and prognosis: Database mining in malignancies
por: Zhao, Shou-Feng, et al.
Publicado: (2019)

PpAKR1A, a Novel Aldo-Keto Reductase from Physcomitrella Patens, Plays a Positive Role in Salt Stress
por: Chen, Lu, et al.
Publicado: (2019)

Aldo-keto Reductase 1C3 (AKR1C3) is Expressed in Differentiated Human Epidermis, Affects Keratinocyte Differentiation and is Upregulated in Atopic Dermatitis
por: Mantel, Alon, et al.
Publicado: (2011)

Immunohistochemistry Detects Increased Expression of Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) in Early-Stage Hepatocellular Carcinoma
por: Han, Chao, et al.
Publicado: (2018)

Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) overexpression in tumors predicts worse overall survival in hepatocellular carcinoma
por: Shi, Jia, et al.
Publicado: (2019)

Prognostic value of aldo-keto reductase family 1 member B10 (AKR1B10) in digestive system cancers: A meta-analysis
por: Liu, Rongqiang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3lqat1f7v5qk7kqu0u74efaejt