Cargando…
Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer
BACKGROUND: Colorectal cancer remains a major public health problem with high morbidity and mortality rates. In the search for the mechanisms of colorectal cancer occurrence and development, increasing attention has been focused on epigenetics. The overall level of Mono-ADP-ribosylation, an epigenet...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7965690/ https://www.ncbi.nlm.nih.gov/pubmed/33737837 http://dx.doi.org/10.2147/CMAR.S303064 |
_version_ | 1783665646441070592 |
---|---|
author | Wang, Chuan-Ling Tang, Yi Li, Ming Xiao, Ming Li, Qing-Shu Yang, Lian Li, Xian Yin, Ling Wang, Ya-Lan |
author_facet | Wang, Chuan-Ling Tang, Yi Li, Ming Xiao, Ming Li, Qing-Shu Yang, Lian Li, Xian Yin, Ling Wang, Ya-Lan |
author_sort | Wang, Chuan-Ling |
collection | PubMed |
description | BACKGROUND: Colorectal cancer remains a major public health problem with high morbidity and mortality rates. In the search for the mechanisms of colorectal cancer occurrence and development, increasing attention has been focused on epigenetics. The overall level of Mono-ADP-ribosylation, an epigenetic, has not been investigated now. The aim of our study was to analysis of the overall level of mono-ADP-ribosylation in colorectal cancer. METHODS: Immunohistochemistry was used to investigate the level of mono-ADP-ribosylation in colorectal cancer and normal colorectal adjacent tissue from 64 CRC patients. The data of patient demographic, clinical and pathological characteristics were acquired and analyzed. RESULTS: Mono-ADP-ribosylation was present in both colorectal adenocarcinoma and normal colorectal tissue. The overall level of mono-ADP-ribosylation in colorectal cancer was significantly higher than that in normal colorectal adjacent tissue. In the nucleus, the majority of samples in the high-level group were colorectal adenocarcinoma (55/64), but the opposite was true for normal colorectal tissues (7/32). In particular, increases in the level of mono-ADP-ribosylation in the cytoplasm of colorectal cancer cells was associated with a greater invasion depth of the tumor. CONCLUSION: The increased level of mono-ADP-ribosylation in colorectal cancer enhances tumor invasion, which suggests that mono-ADP-ribosylation is involved in the development of colorectal cancer and may become a new direction to solve the problem of colorectal cancer. |
format | Online Article Text |
id | pubmed-7965690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-79656902021-03-17 Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer Wang, Chuan-Ling Tang, Yi Li, Ming Xiao, Ming Li, Qing-Shu Yang, Lian Li, Xian Yin, Ling Wang, Ya-Lan Cancer Manag Res Original Research BACKGROUND: Colorectal cancer remains a major public health problem with high morbidity and mortality rates. In the search for the mechanisms of colorectal cancer occurrence and development, increasing attention has been focused on epigenetics. The overall level of Mono-ADP-ribosylation, an epigenetic, has not been investigated now. The aim of our study was to analysis of the overall level of mono-ADP-ribosylation in colorectal cancer. METHODS: Immunohistochemistry was used to investigate the level of mono-ADP-ribosylation in colorectal cancer and normal colorectal adjacent tissue from 64 CRC patients. The data of patient demographic, clinical and pathological characteristics were acquired and analyzed. RESULTS: Mono-ADP-ribosylation was present in both colorectal adenocarcinoma and normal colorectal tissue. The overall level of mono-ADP-ribosylation in colorectal cancer was significantly higher than that in normal colorectal adjacent tissue. In the nucleus, the majority of samples in the high-level group were colorectal adenocarcinoma (55/64), but the opposite was true for normal colorectal tissues (7/32). In particular, increases in the level of mono-ADP-ribosylation in the cytoplasm of colorectal cancer cells was associated with a greater invasion depth of the tumor. CONCLUSION: The increased level of mono-ADP-ribosylation in colorectal cancer enhances tumor invasion, which suggests that mono-ADP-ribosylation is involved in the development of colorectal cancer and may become a new direction to solve the problem of colorectal cancer. Dove 2021-03-12 /pmc/articles/PMC7965690/ /pubmed/33737837 http://dx.doi.org/10.2147/CMAR.S303064 Text en © 2021 Wang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Wang, Chuan-Ling Tang, Yi Li, Ming Xiao, Ming Li, Qing-Shu Yang, Lian Li, Xian Yin, Ling Wang, Ya-Lan Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer |
title | Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer |
title_full | Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer |
title_fullStr | Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer |
title_full_unstemmed | Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer |
title_short | Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer |
title_sort | analysis of mono-adp-ribosylation levels in human colorectal cancer |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7965690/ https://www.ncbi.nlm.nih.gov/pubmed/33737837 http://dx.doi.org/10.2147/CMAR.S303064 |
work_keys_str_mv | AT wangchuanling analysisofmonoadpribosylationlevelsinhumancolorectalcancer AT tangyi analysisofmonoadpribosylationlevelsinhumancolorectalcancer AT liming analysisofmonoadpribosylationlevelsinhumancolorectalcancer AT xiaoming analysisofmonoadpribosylationlevelsinhumancolorectalcancer AT liqingshu analysisofmonoadpribosylationlevelsinhumancolorectalcancer AT yanglian analysisofmonoadpribosylationlevelsinhumancolorectalcancer AT lixian analysisofmonoadpribosylationlevelsinhumancolorectalcancer AT yinling analysisofmonoadpribosylationlevelsinhumancolorectalcancer AT wangyalan analysisofmonoadpribosylationlevelsinhumancolorectalcancer |