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Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer

BACKGROUND: Colorectal cancer remains a major public health problem with high morbidity and mortality rates. In the search for the mechanisms of colorectal cancer occurrence and development, increasing attention has been focused on epigenetics. The overall level of Mono-ADP-ribosylation, an epigenet...

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Autores principales: Wang, Chuan-Ling, Tang, Yi, Li, Ming, Xiao, Ming, Li, Qing-Shu, Yang, Lian, Li, Xian, Yin, Ling, Wang, Ya-Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7965690/
https://www.ncbi.nlm.nih.gov/pubmed/33737837
http://dx.doi.org/10.2147/CMAR.S303064
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author Wang, Chuan-Ling
Tang, Yi
Li, Ming
Xiao, Ming
Li, Qing-Shu
Yang, Lian
Li, Xian
Yin, Ling
Wang, Ya-Lan
author_facet Wang, Chuan-Ling
Tang, Yi
Li, Ming
Xiao, Ming
Li, Qing-Shu
Yang, Lian
Li, Xian
Yin, Ling
Wang, Ya-Lan
author_sort Wang, Chuan-Ling
collection PubMed
description BACKGROUND: Colorectal cancer remains a major public health problem with high morbidity and mortality rates. In the search for the mechanisms of colorectal cancer occurrence and development, increasing attention has been focused on epigenetics. The overall level of Mono-ADP-ribosylation, an epigenetic, has not been investigated now. The aim of our study was to analysis of the overall level of mono-ADP-ribosylation in colorectal cancer. METHODS: Immunohistochemistry was used to investigate the level of mono-ADP-ribosylation in colorectal cancer and normal colorectal adjacent tissue from 64 CRC patients. The data of patient demographic, clinical and pathological characteristics were acquired and analyzed. RESULTS: Mono-ADP-ribosylation was present in both colorectal adenocarcinoma and normal colorectal tissue. The overall level of mono-ADP-ribosylation in colorectal cancer was significantly higher than that in normal colorectal adjacent tissue. In the nucleus, the majority of samples in the high-level group were colorectal adenocarcinoma (55/64), but the opposite was true for normal colorectal tissues (7/32). In particular, increases in the level of mono-ADP-ribosylation in the cytoplasm of colorectal cancer cells was associated with a greater invasion depth of the tumor. CONCLUSION: The increased level of mono-ADP-ribosylation in colorectal cancer enhances tumor invasion, which suggests that mono-ADP-ribosylation is involved in the development of colorectal cancer and may become a new direction to solve the problem of colorectal cancer.
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spelling pubmed-79656902021-03-17 Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer Wang, Chuan-Ling Tang, Yi Li, Ming Xiao, Ming Li, Qing-Shu Yang, Lian Li, Xian Yin, Ling Wang, Ya-Lan Cancer Manag Res Original Research BACKGROUND: Colorectal cancer remains a major public health problem with high morbidity and mortality rates. In the search for the mechanisms of colorectal cancer occurrence and development, increasing attention has been focused on epigenetics. The overall level of Mono-ADP-ribosylation, an epigenetic, has not been investigated now. The aim of our study was to analysis of the overall level of mono-ADP-ribosylation in colorectal cancer. METHODS: Immunohistochemistry was used to investigate the level of mono-ADP-ribosylation in colorectal cancer and normal colorectal adjacent tissue from 64 CRC patients. The data of patient demographic, clinical and pathological characteristics were acquired and analyzed. RESULTS: Mono-ADP-ribosylation was present in both colorectal adenocarcinoma and normal colorectal tissue. The overall level of mono-ADP-ribosylation in colorectal cancer was significantly higher than that in normal colorectal adjacent tissue. In the nucleus, the majority of samples in the high-level group were colorectal adenocarcinoma (55/64), but the opposite was true for normal colorectal tissues (7/32). In particular, increases in the level of mono-ADP-ribosylation in the cytoplasm of colorectal cancer cells was associated with a greater invasion depth of the tumor. CONCLUSION: The increased level of mono-ADP-ribosylation in colorectal cancer enhances tumor invasion, which suggests that mono-ADP-ribosylation is involved in the development of colorectal cancer and may become a new direction to solve the problem of colorectal cancer. Dove 2021-03-12 /pmc/articles/PMC7965690/ /pubmed/33737837 http://dx.doi.org/10.2147/CMAR.S303064 Text en © 2021 Wang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Wang, Chuan-Ling
Tang, Yi
Li, Ming
Xiao, Ming
Li, Qing-Shu
Yang, Lian
Li, Xian
Yin, Ling
Wang, Ya-Lan
Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer
title Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer
title_full Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer
title_fullStr Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer
title_full_unstemmed Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer
title_short Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer
title_sort analysis of mono-adp-ribosylation levels in human colorectal cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7965690/
https://www.ncbi.nlm.nih.gov/pubmed/33737837
http://dx.doi.org/10.2147/CMAR.S303064
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