Cargando…

Quantitative modeling predicts competitive advantages of a next generation anti‐NKG2A monoclonal antibody over monalizumab for the treatment of cancer

A semimechanistic pharmacokinetic (PK)/receptor occupancy (RO) model was constructed to differentiate a next generation anti‐NKG2A monoclonal antibody (KSQ mAb) from monalizumab, an immune checkpoint inhibitor in multiple clinical trials for the treatment of solid tumors. A three‐compartment model i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Spinosa, Phillip, Musial‐Siwek, Monika, Presler, Marc, Betts, Alison, Rosentrater, Emily, Villali, Janice, Wille, Lucia, Zhao, Yang, McCaughtry, Tom, Subramanian, Kalyanasundaram, Liu, Hanlan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7965834/ https://www.ncbi.nlm.nih.gov/pubmed/33501768 http://dx.doi.org/10.1002/psp4.12592

Ejemplares similares

Monalizumab: inhibiting the novel immune checkpoint NKG2A
por: van Hall, Thorbald, et al.
Publicado: (2019)

Innate immunity in COVID-19 patients mediated by NKG2A receptors, and potential treatment using Monalizumab, Cholroquine, and antiviral agents
por: Yaqinuddin, Ahmed, et al.
Publicado: (2020)

Thymic emigration revisited
por: McCaughtry, Tom M., et al.
Publicado: (2007)

Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
por: McCaughtry, Tom M., et al.
Publicado: (2008)

Competitive advantage
por: Anderson, Verl, et al.
Publicado: (2017)

Parental social support, perceived competence and enjoyment in school physical activity
por: Shen, Bo, et al.
Publicado: (2018)

Unleashing NK- and CD8 T cells by combining monalizumab and trastuzumab for metastatic HER2-positive breast cancer: Results of the MIMOSA trial
por: Geurts, V.C.M., et al.
Publicado: (2023)

Speed as competitive advantage
por: Everts, Tammy
Publicado: (2018)

Competitiveness analysis of fresh tomatoes in Indonesia: Turning comparative advantage into competitive advantage
por: Saptana, et al.
Publicado: (2023)

Strategy as action: competitive dynamics and competitive advantage
por: Place, U T, et al.
Publicado: (2005)

What's Your Competitive Advantage?
por: Bowman, Cliff
Publicado: (2018)

The competitive advantage of institutional reward
por: Dong, Yali, et al.
Publicado: (2019)

The competitive advantage of nations : with a new introduction /
por: Porter, Michael E., 1947-
Publicado: (1990)

Environmental structure and competitive scoring advantages in team competitions
por: Merritt, Sears, et al.
Publicado: (2013)

Intratumoral co‐injection of NK cells and NKG2A‐neutralizing monoclonal antibodies
por: Melero, Ignacio, et al.
Publicado: (2023)

Integrating design and manufacturing for competitive advantage
Publicado: (1992)

Create Competitive Advantage with Innovation (Collection)
por: Lord, Michael
Publicado: (2011)

Web Performance as a Competitive Advantage
por: MacDonald, Allyson
Publicado: (2019)

Advantage of Hole Stimulus in Rivalry Competition
por: Meng, Qianli, et al.
Publicado: (2012)

In the pursuit of competitive advantage in ophthalmology services
por: Gheorghe, Consuela Mădălina
Publicado: (2019)

Tacit and ambiguous resources as sources of competitive advantage
por: Ambrosini, V
Publicado: (2003)

Grunting's competitive advantage: Considerations of force and distraction
por: Sinnett, Scott, et al.
Publicado: (2018)

Global sourcing strategy and sustainable competitive advantage
por: Kotabe, Masaaki, et al.
Publicado: (2004)

Germinal Center B Cell Depletion Diminishes CD4(+) Follicular T Helper Cells in Autoimmune Mice
por: Yusuf, Isharat, et al.
Publicado: (2014)

New prospects on the NKG2D/NKG2DL system for oncology
por: Ullrich, Evelyn, et al.
Publicado: (2013)

Fusion Proteins of NKG2D/NKG2DL in Cancer Immunotherapy
por: Ding, Hui, et al.
Publicado: (2018)

Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus
por: McCaughtry, Tom M., et al.
Publicado: (2012)

Does it matter?: information technology and the corrosion of competitive advantage
por: Carr, Nicholas G
Publicado: (2004)

Agile network businesses: collaboration, coordination, and competitive advantage
por: Kale, Vivek
Publicado: (2017)

Leadership results: leading with integrity is your competitive advantage
por: Salicru, Sebastian
Publicado: (2017)

Learning with lean: unleashing the potential for sustainable competitive advantage
por: Zurn, James, et al.
Publicado: (2013)

The power of learning: a guide to gaining competitive advantage
por: Mayo, Andrew, et al.
Publicado: (1994)

Manager Redefined: The Competitive Advantage in the Middle of Your Organization
por: Davenport, Thomas
Publicado: (2010)

Strategy and performance: achieving competitive advantage in the global marketplace
por: Ghobadian, A, et al.
Publicado: (2003)

Design thinking for strategy: innovating towards competitive advantage
por: Diderich, Claude
Publicado: (2019)

COMP-1 promotes competitive advantage of nematode sperm
por: Hansen, Jody M, et al.
Publicado: (2015)

Competitive Advantage in Intercollegiate Athletics: Role of Intangible Resources
por: Won, Doyeon, et al.
Publicado: (2016)

The Emerging Liquid IT Workforce: Theorizing Their Personal Competitive Advantage
por: Marjanovic, Olivera, et al.
Publicado: (2021)

Analysis of competitive and comparative advantages of potato production in Indonesia
por: Saptana,, et al.
Publicado: (2022)

A nasal visual field advantage in interocular competition
por: Sahakian, A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_c96v7sfshvtrqp7p16u1n6bqs5