Physiologically‐based pharmacokinetics modeling to investigate formulation factors influencing the generic substitution of dabigatran etexilate

The exposure‐response relationship of direct acting oral anti‐coagulants (DOACs) for bleeding risk is steep relative to ischemic stroke reduction. As a result, small changes in exposure may lead to bleeding events. The overall goal of this project was to determine the effect of critical formulation...

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Detalles Bibliográficos
Autores principales: Farhan, Nashid, Cristofoletti, Rodrigo, Basu, Sumit, Kim, Sarah, Lingineni, Karthik, Jiang, Sibo, Brown, Joshua D., Fang, Lanyan (Lucy), Lesko, Lawrence J., Schmidt, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7965836/
https://www.ncbi.nlm.nih.gov/pubmed/33449439
http://dx.doi.org/10.1002/psp4.12589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7965836/
https://www.ncbi.nlm.nih.gov/pubmed/33449439
http://dx.doi.org/10.1002/psp4.12589

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