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Both IRBIT and long-IRBIT bind to and coordinately regulate Cl(−)/HCO(3)(−) exchanger AE2 activity through modulating the lysosomal degradation of AE2

Anion exchanger 2 (AE2) plays crucial roles in regulating cell volume homeostasis and cell migration. We found that both IRBIT and Long-IRBIT (L-IRBIT) interact with anion exchanger 2 (AE2). The interaction occurred between the conserved AHCY-homologous domain of IRBIT/L-IRBIT and the N-terminal cyt...

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Detalles Bibliográficos
Autores principales:	Itoh, Ryo, Hatano, Naoya, Murakami, Momoko, Mitsumori, Kosuke, Kawasaki, Satoko, Wakagi, Tomoka, Kanzaki, Yoshino, Kojima, Hiroyuki, Kawaai, Katsuhiro, Mikoshiba, Katsuhiko, Hamada, Koichi, Mizutani, Akihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966362/ https://www.ncbi.nlm.nih.gov/pubmed/33727633 http://dx.doi.org/10.1038/s41598-021-85499-6

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