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Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival

Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here...

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Autores principales: Muzerelle, Aude, Soiza-Reilly, Mariano, Hainer, Cornelia, Ruet, Pierre-Louis, Lesch, Klaus-Peter, Bader, Michael, Alenina, Natalia, Scotto-Lomassese, Sophie, Gaspar, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966367/
https://www.ncbi.nlm.nih.gov/pubmed/33727585
http://dx.doi.org/10.1038/s41598-021-84368-6
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author Muzerelle, Aude
Soiza-Reilly, Mariano
Hainer, Cornelia
Ruet, Pierre-Louis
Lesch, Klaus-Peter
Bader, Michael
Alenina, Natalia
Scotto-Lomassese, Sophie
Gaspar, Patricia
author_facet Muzerelle, Aude
Soiza-Reilly, Mariano
Hainer, Cornelia
Ruet, Pierre-Louis
Lesch, Klaus-Peter
Bader, Michael
Alenina, Natalia
Scotto-Lomassese, Sophie
Gaspar, Patricia
author_sort Muzerelle, Aude
collection PubMed
description Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nursing is responsible for severe growth retardation and early lethality of pups born to hyposerotonergic dams. This nursing defect is due to acute rather constitutive 5-HT depletion, as it is reproduced by adult knockdown of Tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. We conclude that 5-HT innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. Our findings may be related to observations of reduced maternal/infant interactions in human depression.
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spelling pubmed-79663672021-03-19 Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival Muzerelle, Aude Soiza-Reilly, Mariano Hainer, Cornelia Ruet, Pierre-Louis Lesch, Klaus-Peter Bader, Michael Alenina, Natalia Scotto-Lomassese, Sophie Gaspar, Patricia Sci Rep Article Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nursing is responsible for severe growth retardation and early lethality of pups born to hyposerotonergic dams. This nursing defect is due to acute rather constitutive 5-HT depletion, as it is reproduced by adult knockdown of Tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. We conclude that 5-HT innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. Our findings may be related to observations of reduced maternal/infant interactions in human depression. Nature Publishing Group UK 2021-03-16 /pmc/articles/PMC7966367/ /pubmed/33727585 http://dx.doi.org/10.1038/s41598-021-84368-6 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Muzerelle, Aude
Soiza-Reilly, Mariano
Hainer, Cornelia
Ruet, Pierre-Louis
Lesch, Klaus-Peter
Bader, Michael
Alenina, Natalia
Scotto-Lomassese, Sophie
Gaspar, Patricia
Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title_full Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title_fullStr Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title_full_unstemmed Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title_short Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title_sort dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966367/
https://www.ncbi.nlm.nih.gov/pubmed/33727585
http://dx.doi.org/10.1038/s41598-021-84368-6
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