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Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966367/ https://www.ncbi.nlm.nih.gov/pubmed/33727585 http://dx.doi.org/10.1038/s41598-021-84368-6 |
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author | Muzerelle, Aude Soiza-Reilly, Mariano Hainer, Cornelia Ruet, Pierre-Louis Lesch, Klaus-Peter Bader, Michael Alenina, Natalia Scotto-Lomassese, Sophie Gaspar, Patricia |
author_facet | Muzerelle, Aude Soiza-Reilly, Mariano Hainer, Cornelia Ruet, Pierre-Louis Lesch, Klaus-Peter Bader, Michael Alenina, Natalia Scotto-Lomassese, Sophie Gaspar, Patricia |
author_sort | Muzerelle, Aude |
collection | PubMed |
description | Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nursing is responsible for severe growth retardation and early lethality of pups born to hyposerotonergic dams. This nursing defect is due to acute rather constitutive 5-HT depletion, as it is reproduced by adult knockdown of Tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. We conclude that 5-HT innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. Our findings may be related to observations of reduced maternal/infant interactions in human depression. |
format | Online Article Text |
id | pubmed-7966367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79663672021-03-19 Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival Muzerelle, Aude Soiza-Reilly, Mariano Hainer, Cornelia Ruet, Pierre-Louis Lesch, Klaus-Peter Bader, Michael Alenina, Natalia Scotto-Lomassese, Sophie Gaspar, Patricia Sci Rep Article Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nursing is responsible for severe growth retardation and early lethality of pups born to hyposerotonergic dams. This nursing defect is due to acute rather constitutive 5-HT depletion, as it is reproduced by adult knockdown of Tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. We conclude that 5-HT innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. Our findings may be related to observations of reduced maternal/infant interactions in human depression. Nature Publishing Group UK 2021-03-16 /pmc/articles/PMC7966367/ /pubmed/33727585 http://dx.doi.org/10.1038/s41598-021-84368-6 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Muzerelle, Aude Soiza-Reilly, Mariano Hainer, Cornelia Ruet, Pierre-Louis Lesch, Klaus-Peter Bader, Michael Alenina, Natalia Scotto-Lomassese, Sophie Gaspar, Patricia Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival |
title | Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival |
title_full | Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival |
title_fullStr | Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival |
title_full_unstemmed | Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival |
title_short | Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival |
title_sort | dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966367/ https://www.ncbi.nlm.nih.gov/pubmed/33727585 http://dx.doi.org/10.1038/s41598-021-84368-6 |
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