Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction

Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure and one for which no efficacious therapies exist. Obesity and lipid mishandling greatly contribute to HFpEF. However, molecular mechanism(s) governing metabolic alterations and perturbations in lipid hom...

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Detalles Bibliográficos
Autores principales: Schiattarella, Gabriele G., Altamirano, Francisco, Kim, Soo Young, Tong, Dan, Ferdous, Anwarul, Piristine, Hande, Dasgupta, Subhajit, Wang, Xuliang, French, Kristin M., Villalobos, Elisa, Spurgin, Stephen B., Waldman, Maayan, Jiang, Nan, May, Herman I., Hill, Theodore M., Luo, Yuxuan, Yoo, Heesoo, Zaha, Vlad G., Lavandero, Sergio, Gillette, Thomas G., Hill, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966396/
https://www.ncbi.nlm.nih.gov/pubmed/33727534
http://dx.doi.org/10.1038/s41467-021-21931-9

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