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COVID-19-Related Neuropsychiatric Symptoms in Patients With Alcohol Abuse Conditions During the SARS-CoV-2 Pandemic: A Retrospective Cohort Study Using Real World Data From Electronic Health Records of a Tertiary Hospital

Patients with an alcohol abuse disorder exhibit several medical characteristics and social determinants, which suggest a greater vulnerability to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and a worse course of the coronavirus disease 2019 (COVID-19) once infected. Du...

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Autores principales: Varela Rodríguez, Carolina, Arias Horcajadas, Francisco, Martín-Arriscado Arroba, Cristina, Combarro Ripoll, Carolina, Juanes Gonzalez, Alba, Esperesate Pajares, Marina, Rodrigo Holgado, Irene, Cadenas Manceñido, Álvaro, Sánchez Rodríguez, Laura, Baselga Penalva, Blanca, Marín, Marta, Rubio, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966461/
https://www.ncbi.nlm.nih.gov/pubmed/33746884
http://dx.doi.org/10.3389/fneur.2021.630566
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author Varela Rodríguez, Carolina
Arias Horcajadas, Francisco
Martín-Arriscado Arroba, Cristina
Combarro Ripoll, Carolina
Juanes Gonzalez, Alba
Esperesate Pajares, Marina
Rodrigo Holgado, Irene
Cadenas Manceñido, Álvaro
Sánchez Rodríguez, Laura
Baselga Penalva, Blanca
Marín, Marta
Rubio, Gabriel
author_facet Varela Rodríguez, Carolina
Arias Horcajadas, Francisco
Martín-Arriscado Arroba, Cristina
Combarro Ripoll, Carolina
Juanes Gonzalez, Alba
Esperesate Pajares, Marina
Rodrigo Holgado, Irene
Cadenas Manceñido, Álvaro
Sánchez Rodríguez, Laura
Baselga Penalva, Blanca
Marín, Marta
Rubio, Gabriel
author_sort Varela Rodríguez, Carolina
collection PubMed
description Patients with an alcohol abuse disorder exhibit several medical characteristics and social determinants, which suggest a greater vulnerability to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and a worse course of the coronavirus disease 2019 (COVID-19) once infected. During the first wave of the COVID-19, most of the countries have register an increase in alcohol consumption. However, studies on the impact of alcohol addiction on the risk of COVID-19 infection are very scarce and inconclusive. This research offers a descriptive observational retrospective cohort study using real world data obtained from the Electronic Health Records. We found that patients with a personal history of alcohol abuse were 8% more likely to extend their hospitalization length of stay for 1 day (95% CI = 1.04–1.12) and 15% more likely to extend their Intensive Care Unit (ICU) length of stay (95% CI = 1.01–1.30). They were also 5.47 times more at risk of needing an ICU admission (95% CI = 1.61–18.57) and 3.54 times (95% CI = 1.51–8.30) more at risk of needing a respirator. Regarding COVID-19 symptoms, patients with a personal history of alcohol abuse were 91% more likely of exhibiting dyspnea (95% CI = 1.03–3.55) and 3.15 times more at risk of showing at least one neuropsychiatric symptom (95% CI = 1.61–6.17). In addition, they showed statistically significant differences in the number of neuropsychiatric symptoms developed during the COVID-19 infection. Therefore, we strongly recommend to warn of the negative consequences of alcohol abuse over COVID-19 complications. For this purpose. Clinicians should systematically assess history of alcohol issues and drinking habits in all patients, especially for those who seek medical advice regarding COVID-19 infection, in order to predict its severity of symptoms and potential complications. Moreover, this information should be included, in a structured field, into the Electronic Health Record to facilitate the automatic extraction of data, in real time, useful to evaluate the decision-making process in a dynamic context.
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spelling pubmed-79664612021-03-18 COVID-19-Related Neuropsychiatric Symptoms in Patients With Alcohol Abuse Conditions During the SARS-CoV-2 Pandemic: A Retrospective Cohort Study Using Real World Data From Electronic Health Records of a Tertiary Hospital Varela Rodríguez, Carolina Arias Horcajadas, Francisco Martín-Arriscado Arroba, Cristina Combarro Ripoll, Carolina Juanes Gonzalez, Alba Esperesate Pajares, Marina Rodrigo Holgado, Irene Cadenas Manceñido, Álvaro Sánchez Rodríguez, Laura Baselga Penalva, Blanca Marín, Marta Rubio, Gabriel Front Neurol Neurology Patients with an alcohol abuse disorder exhibit several medical characteristics and social determinants, which suggest a greater vulnerability to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and a worse course of the coronavirus disease 2019 (COVID-19) once infected. During the first wave of the COVID-19, most of the countries have register an increase in alcohol consumption. However, studies on the impact of alcohol addiction on the risk of COVID-19 infection are very scarce and inconclusive. This research offers a descriptive observational retrospective cohort study using real world data obtained from the Electronic Health Records. We found that patients with a personal history of alcohol abuse were 8% more likely to extend their hospitalization length of stay for 1 day (95% CI = 1.04–1.12) and 15% more likely to extend their Intensive Care Unit (ICU) length of stay (95% CI = 1.01–1.30). They were also 5.47 times more at risk of needing an ICU admission (95% CI = 1.61–18.57) and 3.54 times (95% CI = 1.51–8.30) more at risk of needing a respirator. Regarding COVID-19 symptoms, patients with a personal history of alcohol abuse were 91% more likely of exhibiting dyspnea (95% CI = 1.03–3.55) and 3.15 times more at risk of showing at least one neuropsychiatric symptom (95% CI = 1.61–6.17). In addition, they showed statistically significant differences in the number of neuropsychiatric symptoms developed during the COVID-19 infection. Therefore, we strongly recommend to warn of the negative consequences of alcohol abuse over COVID-19 complications. For this purpose. Clinicians should systematically assess history of alcohol issues and drinking habits in all patients, especially for those who seek medical advice regarding COVID-19 infection, in order to predict its severity of symptoms and potential complications. Moreover, this information should be included, in a structured field, into the Electronic Health Record to facilitate the automatic extraction of data, in real time, useful to evaluate the decision-making process in a dynamic context. Frontiers Media S.A. 2021-03-03 /pmc/articles/PMC7966461/ /pubmed/33746884 http://dx.doi.org/10.3389/fneur.2021.630566 Text en Copyright © 2021 Varela Rodríguez, Arias Horcajadas, Martín-Arriscado Arroba, Combarro Ripoll, Juanes Gonzalez, Esperesate Pajares, Rodrigo Holgado, Cadenas Manceñido, Sánchez Rodríguez, Baselga Penalva, Marín and Rubio. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Varela Rodríguez, Carolina
Arias Horcajadas, Francisco
Martín-Arriscado Arroba, Cristina
Combarro Ripoll, Carolina
Juanes Gonzalez, Alba
Esperesate Pajares, Marina
Rodrigo Holgado, Irene
Cadenas Manceñido, Álvaro
Sánchez Rodríguez, Laura
Baselga Penalva, Blanca
Marín, Marta
Rubio, Gabriel
COVID-19-Related Neuropsychiatric Symptoms in Patients With Alcohol Abuse Conditions During the SARS-CoV-2 Pandemic: A Retrospective Cohort Study Using Real World Data From Electronic Health Records of a Tertiary Hospital
title COVID-19-Related Neuropsychiatric Symptoms in Patients With Alcohol Abuse Conditions During the SARS-CoV-2 Pandemic: A Retrospective Cohort Study Using Real World Data From Electronic Health Records of a Tertiary Hospital
title_full COVID-19-Related Neuropsychiatric Symptoms in Patients With Alcohol Abuse Conditions During the SARS-CoV-2 Pandemic: A Retrospective Cohort Study Using Real World Data From Electronic Health Records of a Tertiary Hospital
title_fullStr COVID-19-Related Neuropsychiatric Symptoms in Patients With Alcohol Abuse Conditions During the SARS-CoV-2 Pandemic: A Retrospective Cohort Study Using Real World Data From Electronic Health Records of a Tertiary Hospital
title_full_unstemmed COVID-19-Related Neuropsychiatric Symptoms in Patients With Alcohol Abuse Conditions During the SARS-CoV-2 Pandemic: A Retrospective Cohort Study Using Real World Data From Electronic Health Records of a Tertiary Hospital
title_short COVID-19-Related Neuropsychiatric Symptoms in Patients With Alcohol Abuse Conditions During the SARS-CoV-2 Pandemic: A Retrospective Cohort Study Using Real World Data From Electronic Health Records of a Tertiary Hospital
title_sort covid-19-related neuropsychiatric symptoms in patients with alcohol abuse conditions during the sars-cov-2 pandemic: a retrospective cohort study using real world data from electronic health records of a tertiary hospital
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966461/
https://www.ncbi.nlm.nih.gov/pubmed/33746884
http://dx.doi.org/10.3389/fneur.2021.630566
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