Anti-CD19 CARs displayed at the surface of lentiviral vector particles promote transduction of target-expressing cells

Recently, a rare type of relapse was reported upon treating a B cell acute lymphoblastic leukemia (B-ALL) patient with anti-CD19 chimeric antigen receptor (CAR)-T cells caused by unintentional transduction of residual malignant B cells (CAR-B cells). We show that anti-CD19 and anti-CD20 CARs are pre...

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Detalles Bibliográficos
Autores principales: Cordes, Nicole, Kolbe, Carolin, Lock, Dominik, Holzer, Tatjana, Althoff, Deborah, Schäfer, Daniel, Blaeschke, Franziska, Kotter, Bettina, Karitzky, Sandra, Rossig, Claudia, Cathomen, Toni, Feuchtinger, Tobias, Bürger, Iris, Assenmacher, Mario, Schaser, Thomas, Kaiser, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966970/
https://www.ncbi.nlm.nih.gov/pubmed/33768128
http://dx.doi.org/10.1016/j.omtm.2021.02.013

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