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Yellow Nail Syndrome Successfully Treated with Oral Terbinafine and Topical Minoxidil
Yellow nail syndrome (YNS) is a rare disease of unknown etiology that is characterized by varying degrees of pulmonary manifestations, lymphedema, and yellow discoloration of the nails. Herein, we report the efficacy of oral terbinafine and topical minoxidil in treating the associated nail abnormali...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967026/ https://www.ncbi.nlm.nih.gov/pubmed/33746514 http://dx.doi.org/10.2147/CCID.S301197 |
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author | Algain, Maysoon |
author_facet | Algain, Maysoon |
author_sort | Algain, Maysoon |
collection | PubMed |
description | Yellow nail syndrome (YNS) is a rare disease of unknown etiology that is characterized by varying degrees of pulmonary manifestations, lymphedema, and yellow discoloration of the nails. Herein, we report the efficacy of oral terbinafine and topical minoxidil in treating the associated nail abnormalities of YNS in a 66-year-old woman. The patient presented with yellow, brittle, slow-growing nails, which had developed progressively over the past 8 months; left ankle edema; a chronic, purulent, productive cough; and exertional dyspnea. Based on these symptoms, she was diagnosed with YNS. She failed to respond to treatment with fluconazole and vitamin E; however, she was successfully treated with oral terbinafine and topical minoxidil. The treatment was well tolerated, and we speculate that its mode of action includes promoting lymphatic formation and barrier enhancement, thereby improving the distal lymphedema, in addition to distal vasodilation that accelerates the nail growth. To our knowledge, this is the first report of successful treatment of YNS using these agents. |
format | Online Article Text |
id | pubmed-7967026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-79670262021-03-18 Yellow Nail Syndrome Successfully Treated with Oral Terbinafine and Topical Minoxidil Algain, Maysoon Clin Cosmet Investig Dermatol Case Report Yellow nail syndrome (YNS) is a rare disease of unknown etiology that is characterized by varying degrees of pulmonary manifestations, lymphedema, and yellow discoloration of the nails. Herein, we report the efficacy of oral terbinafine and topical minoxidil in treating the associated nail abnormalities of YNS in a 66-year-old woman. The patient presented with yellow, brittle, slow-growing nails, which had developed progressively over the past 8 months; left ankle edema; a chronic, purulent, productive cough; and exertional dyspnea. Based on these symptoms, she was diagnosed with YNS. She failed to respond to treatment with fluconazole and vitamin E; however, she was successfully treated with oral terbinafine and topical minoxidil. The treatment was well tolerated, and we speculate that its mode of action includes promoting lymphatic formation and barrier enhancement, thereby improving the distal lymphedema, in addition to distal vasodilation that accelerates the nail growth. To our knowledge, this is the first report of successful treatment of YNS using these agents. Dove 2021-03-12 /pmc/articles/PMC7967026/ /pubmed/33746514 http://dx.doi.org/10.2147/CCID.S301197 Text en © 2021 Algain. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Case Report Algain, Maysoon Yellow Nail Syndrome Successfully Treated with Oral Terbinafine and Topical Minoxidil |
title | Yellow Nail Syndrome Successfully Treated with Oral Terbinafine and Topical Minoxidil |
title_full | Yellow Nail Syndrome Successfully Treated with Oral Terbinafine and Topical Minoxidil |
title_fullStr | Yellow Nail Syndrome Successfully Treated with Oral Terbinafine and Topical Minoxidil |
title_full_unstemmed | Yellow Nail Syndrome Successfully Treated with Oral Terbinafine and Topical Minoxidil |
title_short | Yellow Nail Syndrome Successfully Treated with Oral Terbinafine and Topical Minoxidil |
title_sort | yellow nail syndrome successfully treated with oral terbinafine and topical minoxidil |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967026/ https://www.ncbi.nlm.nih.gov/pubmed/33746514 http://dx.doi.org/10.2147/CCID.S301197 |
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