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Feasibility of a Dielectric Elastomer Augmented Aorta

Although heart transplantation is a gold standard for severe heart failure, there is a need for alternative effective therapies. A dielectric‐elastomer aorta is used to augment the physiological role of the aorta in the human circulatory system. To this end, the authors developed a tubular dielectri...

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Autores principales: Almanza, Morgan, Clavica, Francesco, Chavanne, Jonathan, Moser, David, Obrist, Dominik, Carrel, Thierry, Civet, Yoan, Perriard, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967089/
https://www.ncbi.nlm.nih.gov/pubmed/33747718
http://dx.doi.org/10.1002/advs.202001974
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author Almanza, Morgan
Clavica, Francesco
Chavanne, Jonathan
Moser, David
Obrist, Dominik
Carrel, Thierry
Civet, Yoan
Perriard, Yves
author_facet Almanza, Morgan
Clavica, Francesco
Chavanne, Jonathan
Moser, David
Obrist, Dominik
Carrel, Thierry
Civet, Yoan
Perriard, Yves
author_sort Almanza, Morgan
collection PubMed
description Although heart transplantation is a gold standard for severe heart failure, there is a need for alternative effective therapies. A dielectric‐elastomer aorta is used to augment the physiological role of the aorta in the human circulatory system. To this end, the authors developed a tubular dielectric elastomer actuator (DEA) able to assist the heart by easing the deformation of the aorta in the systole and by increasing its recoil force in the diastole. In vitro experiments using a pulsatile flow‐loop, replicating human physiological flow and pressure conditions, show a reduction of 5.5% (47 mJ per cycle) of the heart energy with this device. Here, the controlled stiffness of the DEA graft, which is usually difficult to exploit for actuators, is perfectly matching the assistance principle. At the same time, the physiological aortic pressure is exploited to offer a prestretch to the DEA which otherwise would require an additional bulky pre‐stretching system to reach high performances.
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spelling pubmed-79670892021-03-19 Feasibility of a Dielectric Elastomer Augmented Aorta Almanza, Morgan Clavica, Francesco Chavanne, Jonathan Moser, David Obrist, Dominik Carrel, Thierry Civet, Yoan Perriard, Yves Adv Sci (Weinh) Full Papers Although heart transplantation is a gold standard for severe heart failure, there is a need for alternative effective therapies. A dielectric‐elastomer aorta is used to augment the physiological role of the aorta in the human circulatory system. To this end, the authors developed a tubular dielectric elastomer actuator (DEA) able to assist the heart by easing the deformation of the aorta in the systole and by increasing its recoil force in the diastole. In vitro experiments using a pulsatile flow‐loop, replicating human physiological flow and pressure conditions, show a reduction of 5.5% (47 mJ per cycle) of the heart energy with this device. Here, the controlled stiffness of the DEA graft, which is usually difficult to exploit for actuators, is perfectly matching the assistance principle. At the same time, the physiological aortic pressure is exploited to offer a prestretch to the DEA which otherwise would require an additional bulky pre‐stretching system to reach high performances. John Wiley and Sons Inc. 2021-01-25 /pmc/articles/PMC7967089/ /pubmed/33747718 http://dx.doi.org/10.1002/advs.202001974 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Papers
Almanza, Morgan
Clavica, Francesco
Chavanne, Jonathan
Moser, David
Obrist, Dominik
Carrel, Thierry
Civet, Yoan
Perriard, Yves
Feasibility of a Dielectric Elastomer Augmented Aorta
title Feasibility of a Dielectric Elastomer Augmented Aorta
title_full Feasibility of a Dielectric Elastomer Augmented Aorta
title_fullStr Feasibility of a Dielectric Elastomer Augmented Aorta
title_full_unstemmed Feasibility of a Dielectric Elastomer Augmented Aorta
title_short Feasibility of a Dielectric Elastomer Augmented Aorta
title_sort feasibility of a dielectric elastomer augmented aorta
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967089/
https://www.ncbi.nlm.nih.gov/pubmed/33747718
http://dx.doi.org/10.1002/advs.202001974
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