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Feasibility of a Dielectric Elastomer Augmented Aorta
Although heart transplantation is a gold standard for severe heart failure, there is a need for alternative effective therapies. A dielectric‐elastomer aorta is used to augment the physiological role of the aorta in the human circulatory system. To this end, the authors developed a tubular dielectri...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967089/ https://www.ncbi.nlm.nih.gov/pubmed/33747718 http://dx.doi.org/10.1002/advs.202001974 |
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author | Almanza, Morgan Clavica, Francesco Chavanne, Jonathan Moser, David Obrist, Dominik Carrel, Thierry Civet, Yoan Perriard, Yves |
author_facet | Almanza, Morgan Clavica, Francesco Chavanne, Jonathan Moser, David Obrist, Dominik Carrel, Thierry Civet, Yoan Perriard, Yves |
author_sort | Almanza, Morgan |
collection | PubMed |
description | Although heart transplantation is a gold standard for severe heart failure, there is a need for alternative effective therapies. A dielectric‐elastomer aorta is used to augment the physiological role of the aorta in the human circulatory system. To this end, the authors developed a tubular dielectric elastomer actuator (DEA) able to assist the heart by easing the deformation of the aorta in the systole and by increasing its recoil force in the diastole. In vitro experiments using a pulsatile flow‐loop, replicating human physiological flow and pressure conditions, show a reduction of 5.5% (47 mJ per cycle) of the heart energy with this device. Here, the controlled stiffness of the DEA graft, which is usually difficult to exploit for actuators, is perfectly matching the assistance principle. At the same time, the physiological aortic pressure is exploited to offer a prestretch to the DEA which otherwise would require an additional bulky pre‐stretching system to reach high performances. |
format | Online Article Text |
id | pubmed-7967089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79670892021-03-19 Feasibility of a Dielectric Elastomer Augmented Aorta Almanza, Morgan Clavica, Francesco Chavanne, Jonathan Moser, David Obrist, Dominik Carrel, Thierry Civet, Yoan Perriard, Yves Adv Sci (Weinh) Full Papers Although heart transplantation is a gold standard for severe heart failure, there is a need for alternative effective therapies. A dielectric‐elastomer aorta is used to augment the physiological role of the aorta in the human circulatory system. To this end, the authors developed a tubular dielectric elastomer actuator (DEA) able to assist the heart by easing the deformation of the aorta in the systole and by increasing its recoil force in the diastole. In vitro experiments using a pulsatile flow‐loop, replicating human physiological flow and pressure conditions, show a reduction of 5.5% (47 mJ per cycle) of the heart energy with this device. Here, the controlled stiffness of the DEA graft, which is usually difficult to exploit for actuators, is perfectly matching the assistance principle. At the same time, the physiological aortic pressure is exploited to offer a prestretch to the DEA which otherwise would require an additional bulky pre‐stretching system to reach high performances. John Wiley and Sons Inc. 2021-01-25 /pmc/articles/PMC7967089/ /pubmed/33747718 http://dx.doi.org/10.1002/advs.202001974 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Full Papers Almanza, Morgan Clavica, Francesco Chavanne, Jonathan Moser, David Obrist, Dominik Carrel, Thierry Civet, Yoan Perriard, Yves Feasibility of a Dielectric Elastomer Augmented Aorta |
title | Feasibility of a Dielectric Elastomer Augmented Aorta |
title_full | Feasibility of a Dielectric Elastomer Augmented Aorta |
title_fullStr | Feasibility of a Dielectric Elastomer Augmented Aorta |
title_full_unstemmed | Feasibility of a Dielectric Elastomer Augmented Aorta |
title_short | Feasibility of a Dielectric Elastomer Augmented Aorta |
title_sort | feasibility of a dielectric elastomer augmented aorta |
topic | Full Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967089/ https://www.ncbi.nlm.nih.gov/pubmed/33747718 http://dx.doi.org/10.1002/advs.202001974 |
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