Design and Synthesis of Non-Covalent Imidazo[1,2-a]quinoxaline-Based Inhibitors of EGFR and Their Anti-Cancer Assessment

A series of 30 non-covalent imidazo[1,2-a]quinoxaline-based inhibitors of epidermal growth factor receptor (EGFR) were designed and synthesized. EGFR inhibitory assessment (against wild type) data of compounds revealed 6b, 7h, 7j, 9a and 9c as potent EGFR(WT) inhibitors with IC(50) values of 211.22,...

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Detalles Bibliográficos
Autores principales: Kumar, Manvendra, Joshi, Gaurav, Arora, Sahil, Singh, Tashvinder, Biswas, Sajal, Sharma, Nisha, Bhat, Zahid Rafiq, Tikoo, Kulbhushan, Singh, Sandeep, Kumar, Raj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967119/
https://www.ncbi.nlm.nih.gov/pubmed/33803355
http://dx.doi.org/10.3390/molecules26051490

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