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Deletion of Irf4 in T Cells Suppressed Autoimmune Uveitis and Dysregulated Transcriptional Programs Linked to CD4(+) T Cell Differentiation and Metabolism

Interferon regulatory factor-4 (IRF4) and IRF8 regulate differentiation, growth and functions of lymphoid and myeloid cells. Targeted deletion of irf8 in T cells (CD4-IRF8KO) has been shown to exacerbate colitis and experimental autoimmune uveitis (EAU), a mouse model of human uveitis. We therefore...

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Detalles Bibliográficos
Autores principales:	Kang, Minkyung, Lee, Hyun-Su, Choi, Jin Kyeong, Yu, Cheng-Rong, Egwuagu, Charles E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967141/ https://www.ncbi.nlm.nih.gov/pubmed/33803441 http://dx.doi.org/10.3390/ijms22052775

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