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Genetic stabilization by p53 involves growth regulatory and repair pathways

p53 performs a plethora of activities, which are directed towards the maintenance of the genomic integrity and constitute its universal role as a tumor suppressor. 1000 to 10000 latent p53 molecules are permanently available in order to monitor DNA exchange processes in mitotically growing cells. Af...

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Detalles Bibliográficos
Autor principal: Wiesmüller, Lisa
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC79672/
https://www.ncbi.nlm.nih.gov/pubmed/12488620
http://dx.doi.org/10.1155/S1110724301000043
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author Wiesmüller, Lisa
author_facet Wiesmüller, Lisa
author_sort Wiesmüller, Lisa
collection PubMed
description p53 performs a plethora of activities, which are directed towards the maintenance of the genomic integrity and constitute its universal role as a tumor suppressor. 1000 to 10000 latent p53 molecules are permanently available in order to monitor DNA exchange processes in mitotically growing cells. After the introduction of major DNA injuries the levels of posttranslationally modified p53 proteins rise, which in turn transcriptionally signal transient cell cycle arrest or apoptotic cell death, depending on the extent of damage. Taken together, p53 inhibits the manifestation of genomic instabilities at different control levels both during naturally occurring metabolic processes and in response to genotoxic treatments.
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spelling pubmed-796722002-03-12 Genetic stabilization by p53 involves growth regulatory and repair pathways Wiesmüller, Lisa J Biomed Biotechnol Review Article p53 performs a plethora of activities, which are directed towards the maintenance of the genomic integrity and constitute its universal role as a tumor suppressor. 1000 to 10000 latent p53 molecules are permanently available in order to monitor DNA exchange processes in mitotically growing cells. After the introduction of major DNA injuries the levels of posttranslationally modified p53 proteins rise, which in turn transcriptionally signal transient cell cycle arrest or apoptotic cell death, depending on the extent of damage. Taken together, p53 inhibits the manifestation of genomic instabilities at different control levels both during naturally occurring metabolic processes and in response to genotoxic treatments. Hindawi Publishing Corporation 2001 /pmc/articles/PMC79672/ /pubmed/12488620 http://dx.doi.org/10.1155/S1110724301000043 Text en Copyright © 2001, Hindawi Publishing Corporation
spellingShingle Review Article
Wiesmüller, Lisa
Genetic stabilization by p53 involves growth regulatory and repair pathways
title Genetic stabilization by p53 involves growth regulatory and repair pathways
title_full Genetic stabilization by p53 involves growth regulatory and repair pathways
title_fullStr Genetic stabilization by p53 involves growth regulatory and repair pathways
title_full_unstemmed Genetic stabilization by p53 involves growth regulatory and repair pathways
title_short Genetic stabilization by p53 involves growth regulatory and repair pathways
title_sort genetic stabilization by p53 involves growth regulatory and repair pathways
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC79672/
https://www.ncbi.nlm.nih.gov/pubmed/12488620
http://dx.doi.org/10.1155/S1110724301000043
work_keys_str_mv AT wiesmullerlisa geneticstabilizationbyp53involvesgrowthregulatoryandrepairpathways