Breaching the kinetic barrier to in vitro somatic stem cell propagation

ABSTRACT: Here we have reviewed the conventional definitions and fundamental characteristics of the two basic types of stem cells, embryonic stem cells (ESCs) and somatic stem cells (SSCs). By taking into account the often-overlooked asymmetric cell kinetics of SSCs, we consider the evidence that sh...

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Detalles Bibliográficos
Autores principales: Merok, Joshua R, Sherley, James L
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2001
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC79674/
https://www.ncbi.nlm.nih.gov/pubmed/12488623
http://dx.doi.org/10.1155/S1110724301000067
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author Merok, Joshua R
Sherley, James L
author_facet Merok, Joshua R
Sherley, James L
author_sort Merok, Joshua R
collection PubMed
description ABSTRACT: Here we have reviewed the conventional definitions and fundamental characteristics of the two basic types of stem cells, embryonic stem cells (ESCs) and somatic stem cells (SSCs). By taking into account the often-overlooked asymmetric cell kinetics of SSCs, we consider the evidence that should SSCs retain these growth kinetics in vitro, a natural kinetic barrier to SSC propagation exists. Recent discoveries showing that the tumor suppressor gene p53 can act as a regulator of asymmetric cell kinetics provide a target pathway for in vitro SSC propagation strategies.
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spelling pubmed-796742002-03-12 Breaching the kinetic barrier to in vitro somatic stem cell propagation Merok, Joshua R Sherley, James L J Biomed Biotechnol Perspective ABSTRACT: Here we have reviewed the conventional definitions and fundamental characteristics of the two basic types of stem cells, embryonic stem cells (ESCs) and somatic stem cells (SSCs). By taking into account the often-overlooked asymmetric cell kinetics of SSCs, we consider the evidence that should SSCs retain these growth kinetics in vitro, a natural kinetic barrier to SSC propagation exists. Recent discoveries showing that the tumor suppressor gene p53 can act as a regulator of asymmetric cell kinetics provide a target pathway for in vitro SSC propagation strategies. Hindawi Publishing Corporation 2001 /pmc/articles/PMC79674/ /pubmed/12488623 http://dx.doi.org/10.1155/S1110724301000067 Text en Copyright © 2001, Hindawi Publishing Corporation
spellingShingle Perspective
Merok, Joshua R
Sherley, James L
Breaching the kinetic barrier to in vitro somatic stem cell propagation
title Breaching the kinetic barrier to in vitro somatic stem cell propagation
title_full Breaching the kinetic barrier to in vitro somatic stem cell propagation
title_fullStr Breaching the kinetic barrier to in vitro somatic stem cell propagation
title_full_unstemmed Breaching the kinetic barrier to in vitro somatic stem cell propagation
title_short Breaching the kinetic barrier to in vitro somatic stem cell propagation
title_sort breaching the kinetic barrier to in vitro somatic stem cell propagation
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC79674/
https://www.ncbi.nlm.nih.gov/pubmed/12488623
http://dx.doi.org/10.1155/S1110724301000067
work_keys_str_mv AT merokjoshuar breachingthekineticbarriertoinvitrosomaticstemcellpropagation
AT sherleyjamesl breachingthekineticbarriertoinvitrosomaticstemcellpropagation

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