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Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study

This study aimed to clarify the association between uterine myomas and preterm birth (PTB), preterm premature rupture of membranes (pPROM), and intrauterine infection (II). The study was based on data from the Japan Environment and Children’s Study, a nationwide birth-cohort study. Data of 86,370 wo...

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Autores principales: Murata, Tsuyoshi, Kyozuka, Hyo, Endo, Yuta, Fukuda, Toma, Yasuda, Shun, Yamaguchi, Akiko, Sato, Akiko, Ogata, Yuka, Shinoki, Kosei, Hosoya, Mitsuaki, Yasumura, Seiji, Hashimoto, Koichi, Nishigori, Hidekazu, Fujimori, Keiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967712/
https://www.ncbi.nlm.nih.gov/pubmed/33668326
http://dx.doi.org/10.3390/ijerph18052246
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author Murata, Tsuyoshi
Kyozuka, Hyo
Endo, Yuta
Fukuda, Toma
Yasuda, Shun
Yamaguchi, Akiko
Sato, Akiko
Ogata, Yuka
Shinoki, Kosei
Hosoya, Mitsuaki
Yasumura, Seiji
Hashimoto, Koichi
Nishigori, Hidekazu
Fujimori, Keiya
author_facet Murata, Tsuyoshi
Kyozuka, Hyo
Endo, Yuta
Fukuda, Toma
Yasuda, Shun
Yamaguchi, Akiko
Sato, Akiko
Ogata, Yuka
Shinoki, Kosei
Hosoya, Mitsuaki
Yasumura, Seiji
Hashimoto, Koichi
Nishigori, Hidekazu
Fujimori, Keiya
author_sort Murata, Tsuyoshi
collection PubMed
description This study aimed to clarify the association between uterine myomas and preterm birth (PTB), preterm premature rupture of membranes (pPROM), and intrauterine infection (II). The study was based on data from the Japan Environment and Children’s Study, a nationwide birth-cohort study. Data of 86,370 women with singleton births after 22 weeks of gestation (with uterine myomas, n = 5354) were retrospectively analyzed. Using logistic regression, adjusted odds ratios (aORs) for PTB, pPROM, and II were calculated considering women without uterine myomas as the reference. Additionally, the effects of II on the incidence of PTB and pPROM were evaluated. In women with uterine myomas, the aORs for PTB before 37 and 34 weeks, pPROM, and II were 1.37 (95% confidence interval, 1.22–1.54), 1.61 (1.27–2.05), 1.65 (1.33–2.04), and 1.05 (0.75–1.46), respectively. The aORs for PTB and pPROM in women with II and uterine myomas were not significantly increased. Uterine myomas during pregnancy were associated with an increased incidence of PTB and pPROM. However, II in women with uterine myomas was not associated with an increased incidence of PTB or pPROM. These findings suggest a potential risk of occult PTB in pregnant women with uterine myomas.
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spelling pubmed-79677122021-03-18 Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study Murata, Tsuyoshi Kyozuka, Hyo Endo, Yuta Fukuda, Toma Yasuda, Shun Yamaguchi, Akiko Sato, Akiko Ogata, Yuka Shinoki, Kosei Hosoya, Mitsuaki Yasumura, Seiji Hashimoto, Koichi Nishigori, Hidekazu Fujimori, Keiya Int J Environ Res Public Health Article This study aimed to clarify the association between uterine myomas and preterm birth (PTB), preterm premature rupture of membranes (pPROM), and intrauterine infection (II). The study was based on data from the Japan Environment and Children’s Study, a nationwide birth-cohort study. Data of 86,370 women with singleton births after 22 weeks of gestation (with uterine myomas, n = 5354) were retrospectively analyzed. Using logistic regression, adjusted odds ratios (aORs) for PTB, pPROM, and II were calculated considering women without uterine myomas as the reference. Additionally, the effects of II on the incidence of PTB and pPROM were evaluated. In women with uterine myomas, the aORs for PTB before 37 and 34 weeks, pPROM, and II were 1.37 (95% confidence interval, 1.22–1.54), 1.61 (1.27–2.05), 1.65 (1.33–2.04), and 1.05 (0.75–1.46), respectively. The aORs for PTB and pPROM in women with II and uterine myomas were not significantly increased. Uterine myomas during pregnancy were associated with an increased incidence of PTB and pPROM. However, II in women with uterine myomas was not associated with an increased incidence of PTB or pPROM. These findings suggest a potential risk of occult PTB in pregnant women with uterine myomas. MDPI 2021-02-24 /pmc/articles/PMC7967712/ /pubmed/33668326 http://dx.doi.org/10.3390/ijerph18052246 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Murata, Tsuyoshi
Kyozuka, Hyo
Endo, Yuta
Fukuda, Toma
Yasuda, Shun
Yamaguchi, Akiko
Sato, Akiko
Ogata, Yuka
Shinoki, Kosei
Hosoya, Mitsuaki
Yasumura, Seiji
Hashimoto, Koichi
Nishigori, Hidekazu
Fujimori, Keiya
Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study
title Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study
title_full Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study
title_fullStr Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study
title_full_unstemmed Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study
title_short Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study
title_sort preterm deliveries in women with uterine myomas: the japan environment and children’s study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967712/
https://www.ncbi.nlm.nih.gov/pubmed/33668326
http://dx.doi.org/10.3390/ijerph18052246
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