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Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study
This study aimed to clarify the association between uterine myomas and preterm birth (PTB), preterm premature rupture of membranes (pPROM), and intrauterine infection (II). The study was based on data from the Japan Environment and Children’s Study, a nationwide birth-cohort study. Data of 86,370 wo...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967712/ https://www.ncbi.nlm.nih.gov/pubmed/33668326 http://dx.doi.org/10.3390/ijerph18052246 |
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author | Murata, Tsuyoshi Kyozuka, Hyo Endo, Yuta Fukuda, Toma Yasuda, Shun Yamaguchi, Akiko Sato, Akiko Ogata, Yuka Shinoki, Kosei Hosoya, Mitsuaki Yasumura, Seiji Hashimoto, Koichi Nishigori, Hidekazu Fujimori, Keiya |
author_facet | Murata, Tsuyoshi Kyozuka, Hyo Endo, Yuta Fukuda, Toma Yasuda, Shun Yamaguchi, Akiko Sato, Akiko Ogata, Yuka Shinoki, Kosei Hosoya, Mitsuaki Yasumura, Seiji Hashimoto, Koichi Nishigori, Hidekazu Fujimori, Keiya |
author_sort | Murata, Tsuyoshi |
collection | PubMed |
description | This study aimed to clarify the association between uterine myomas and preterm birth (PTB), preterm premature rupture of membranes (pPROM), and intrauterine infection (II). The study was based on data from the Japan Environment and Children’s Study, a nationwide birth-cohort study. Data of 86,370 women with singleton births after 22 weeks of gestation (with uterine myomas, n = 5354) were retrospectively analyzed. Using logistic regression, adjusted odds ratios (aORs) for PTB, pPROM, and II were calculated considering women without uterine myomas as the reference. Additionally, the effects of II on the incidence of PTB and pPROM were evaluated. In women with uterine myomas, the aORs for PTB before 37 and 34 weeks, pPROM, and II were 1.37 (95% confidence interval, 1.22–1.54), 1.61 (1.27–2.05), 1.65 (1.33–2.04), and 1.05 (0.75–1.46), respectively. The aORs for PTB and pPROM in women with II and uterine myomas were not significantly increased. Uterine myomas during pregnancy were associated with an increased incidence of PTB and pPROM. However, II in women with uterine myomas was not associated with an increased incidence of PTB or pPROM. These findings suggest a potential risk of occult PTB in pregnant women with uterine myomas. |
format | Online Article Text |
id | pubmed-7967712 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79677122021-03-18 Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study Murata, Tsuyoshi Kyozuka, Hyo Endo, Yuta Fukuda, Toma Yasuda, Shun Yamaguchi, Akiko Sato, Akiko Ogata, Yuka Shinoki, Kosei Hosoya, Mitsuaki Yasumura, Seiji Hashimoto, Koichi Nishigori, Hidekazu Fujimori, Keiya Int J Environ Res Public Health Article This study aimed to clarify the association between uterine myomas and preterm birth (PTB), preterm premature rupture of membranes (pPROM), and intrauterine infection (II). The study was based on data from the Japan Environment and Children’s Study, a nationwide birth-cohort study. Data of 86,370 women with singleton births after 22 weeks of gestation (with uterine myomas, n = 5354) were retrospectively analyzed. Using logistic regression, adjusted odds ratios (aORs) for PTB, pPROM, and II were calculated considering women without uterine myomas as the reference. Additionally, the effects of II on the incidence of PTB and pPROM were evaluated. In women with uterine myomas, the aORs for PTB before 37 and 34 weeks, pPROM, and II were 1.37 (95% confidence interval, 1.22–1.54), 1.61 (1.27–2.05), 1.65 (1.33–2.04), and 1.05 (0.75–1.46), respectively. The aORs for PTB and pPROM in women with II and uterine myomas were not significantly increased. Uterine myomas during pregnancy were associated with an increased incidence of PTB and pPROM. However, II in women with uterine myomas was not associated with an increased incidence of PTB or pPROM. These findings suggest a potential risk of occult PTB in pregnant women with uterine myomas. MDPI 2021-02-24 /pmc/articles/PMC7967712/ /pubmed/33668326 http://dx.doi.org/10.3390/ijerph18052246 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Murata, Tsuyoshi Kyozuka, Hyo Endo, Yuta Fukuda, Toma Yasuda, Shun Yamaguchi, Akiko Sato, Akiko Ogata, Yuka Shinoki, Kosei Hosoya, Mitsuaki Yasumura, Seiji Hashimoto, Koichi Nishigori, Hidekazu Fujimori, Keiya Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study |
title | Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study |
title_full | Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study |
title_fullStr | Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study |
title_full_unstemmed | Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study |
title_short | Preterm Deliveries in Women with Uterine Myomas: The Japan Environment and Children’s Study |
title_sort | preterm deliveries in women with uterine myomas: the japan environment and children’s study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967712/ https://www.ncbi.nlm.nih.gov/pubmed/33668326 http://dx.doi.org/10.3390/ijerph18052246 |
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