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Bedeutung von Citicolin bei der Glaukomerkrankung

BACKGROUND: In recent years, many experimental and clinical studies have shown that in glaucoma, neuronal degeneration occurs not only at the level of the retina and optic nerve, but also along the entire visual pathway and the brain. OBJECTIVE: This article presents the neuroprotective effects of c...

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Autores principales: Jünemann, Anselm G. M., Grieb, P., Rejdak, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Medizin 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967777/
https://www.ncbi.nlm.nih.gov/pubmed/33730306
http://dx.doi.org/10.1007/s00347-021-01362-z
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author Jünemann, Anselm G. M.
Grieb, P.
Rejdak, R.
author_facet Jünemann, Anselm G. M.
Grieb, P.
Rejdak, R.
author_sort Jünemann, Anselm G. M.
collection PubMed
description BACKGROUND: In recent years, many experimental and clinical studies have shown that in glaucoma, neuronal degeneration occurs not only at the level of the retina and optic nerve, but also along the entire visual pathway and the brain. OBJECTIVE: This article presents the neuroprotective effects of citicoline and their mechanisms in glaucoma disease. MATERIALS AND METHODS: The relevance of citicoline is explained against the background of neuroanatomy, neuroimaging, and the pathogenesis of glaucoma. Data from experimental and clinical studies are presented and a conclusion is drawn for clinical application. RESULTS: Citicoline has a neuroprotective effect via mechanisms relevant to glaucoma. The neuroprotective effect of citicoline in open-angle glaucoma can be demonstrated functionally and morphologically. It is independent of the glaucoma damage and intraocular pressure, and usually occurs only after 1 year. The effects of oral citicoline occur at a daily dose of 500–1000 mg. Citicoline can be taken permanently or in cycles. No side effects occurred in the studies when taking citicoline. Citicoline can improve cognitive performance and thus treatment adherence as well as quality of life in glaucoma patients. CONCLUSION: This relatively old nootropic drug, which is now marketed as a food supplement, seems to be a valuable addition to conventional treatment and also a rational option for prophylaxis of open-angle glaucoma.
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spelling pubmed-79677772021-03-17 Bedeutung von Citicolin bei der Glaukomerkrankung Jünemann, Anselm G. M. Grieb, P. Rejdak, R. Ophthalmologe Leitthema BACKGROUND: In recent years, many experimental and clinical studies have shown that in glaucoma, neuronal degeneration occurs not only at the level of the retina and optic nerve, but also along the entire visual pathway and the brain. OBJECTIVE: This article presents the neuroprotective effects of citicoline and their mechanisms in glaucoma disease. MATERIALS AND METHODS: The relevance of citicoline is explained against the background of neuroanatomy, neuroimaging, and the pathogenesis of glaucoma. Data from experimental and clinical studies are presented and a conclusion is drawn for clinical application. RESULTS: Citicoline has a neuroprotective effect via mechanisms relevant to glaucoma. The neuroprotective effect of citicoline in open-angle glaucoma can be demonstrated functionally and morphologically. It is independent of the glaucoma damage and intraocular pressure, and usually occurs only after 1 year. The effects of oral citicoline occur at a daily dose of 500–1000 mg. Citicoline can be taken permanently or in cycles. No side effects occurred in the studies when taking citicoline. Citicoline can improve cognitive performance and thus treatment adherence as well as quality of life in glaucoma patients. CONCLUSION: This relatively old nootropic drug, which is now marketed as a food supplement, seems to be a valuable addition to conventional treatment and also a rational option for prophylaxis of open-angle glaucoma. Springer Medizin 2021-03-17 2021 /pmc/articles/PMC7967777/ /pubmed/33730306 http://dx.doi.org/10.1007/s00347-021-01362-z Text en © Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Leitthema
Jünemann, Anselm G. M.
Grieb, P.
Rejdak, R.
Bedeutung von Citicolin bei der Glaukomerkrankung
title Bedeutung von Citicolin bei der Glaukomerkrankung
title_full Bedeutung von Citicolin bei der Glaukomerkrankung
title_fullStr Bedeutung von Citicolin bei der Glaukomerkrankung
title_full_unstemmed Bedeutung von Citicolin bei der Glaukomerkrankung
title_short Bedeutung von Citicolin bei der Glaukomerkrankung
title_sort bedeutung von citicolin bei der glaukomerkrankung
topic Leitthema
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967777/
https://www.ncbi.nlm.nih.gov/pubmed/33730306
http://dx.doi.org/10.1007/s00347-021-01362-z
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