COVID-19 highlights the model dilemma in biomedical research

Scientists worldwide struggle to identify suitable animal models to study SARS-CoV-2 infections. Interspecies-related differences, such as host specificity, divergent immune responses, or the unavailability of species-specific reagents hamper the research. Human-based models, such as micro-engineere...

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Detalles Bibliográficos
Autores principales: Adhikary, Partho Protim, Ul Ain, Qurrat, Hocke, Andreas Christian, Hedtrich, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967778/
https://www.ncbi.nlm.nih.gov/pubmed/33747552
http://dx.doi.org/10.1038/s41578-021-00305-z
Descripción
Sumario:Scientists worldwide struggle to identify suitable animal models to study SARS-CoV-2 infections. Interspecies-related differences, such as host specificity, divergent immune responses, or the unavailability of species-specific reagents hamper the research. Human-based models, such as micro-engineered multi-organs-on-chip, may hold the solution.

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