COVID-19 highlights the model dilemma in biomedical research

Scientists worldwide struggle to identify suitable animal models to study SARS-CoV-2 infections. Interspecies-related differences, such as host specificity, divergent immune responses, or the unavailability of species-specific reagents hamper the research. Human-based models, such as micro-engineere...

Descripción completa

Detalles Bibliográficos
Autores principales: Adhikary, Partho Protim, Ul Ain, Qurrat, Hocke, Andreas Christian, Hedtrich, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967778/
https://www.ncbi.nlm.nih.gov/pubmed/33747552
http://dx.doi.org/10.1038/s41578-021-00305-z
_version_ 1783665954197078016
author Adhikary, Partho Protim
Ul Ain, Qurrat
Hocke, Andreas Christian
Hedtrich, Sarah
author_facet Adhikary, Partho Protim
Ul Ain, Qurrat
Hocke, Andreas Christian
Hedtrich, Sarah
author_sort Adhikary, Partho Protim
collection PubMed
description Scientists worldwide struggle to identify suitable animal models to study SARS-CoV-2 infections. Interspecies-related differences, such as host specificity, divergent immune responses, or the unavailability of species-specific reagents hamper the research. Human-based models, such as micro-engineered multi-organs-on-chip, may hold the solution.
format Online
Article
Text
id pubmed-7967778
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-79677782021-03-17 COVID-19 highlights the model dilemma in biomedical research Adhikary, Partho Protim Ul Ain, Qurrat Hocke, Andreas Christian Hedtrich, Sarah Nat Rev Mater Comment Scientists worldwide struggle to identify suitable animal models to study SARS-CoV-2 infections. Interspecies-related differences, such as host specificity, divergent immune responses, or the unavailability of species-specific reagents hamper the research. Human-based models, such as micro-engineered multi-organs-on-chip, may hold the solution. Nature Publishing Group UK 2021-03-17 2021 /pmc/articles/PMC7967778/ /pubmed/33747552 http://dx.doi.org/10.1038/s41578-021-00305-z Text en © Springer Nature Limited 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Adhikary, Partho Protim
Ul Ain, Qurrat
Hocke, Andreas Christian
Hedtrich, Sarah
COVID-19 highlights the model dilemma in biomedical research
title COVID-19 highlights the model dilemma in biomedical research
title_full COVID-19 highlights the model dilemma in biomedical research
title_fullStr COVID-19 highlights the model dilemma in biomedical research
title_full_unstemmed COVID-19 highlights the model dilemma in biomedical research
title_short COVID-19 highlights the model dilemma in biomedical research
title_sort covid-19 highlights the model dilemma in biomedical research
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967778/
https://www.ncbi.nlm.nih.gov/pubmed/33747552
http://dx.doi.org/10.1038/s41578-021-00305-z
work_keys_str_mv AT adhikaryparthoprotim covid19highlightsthemodeldilemmainbiomedicalresearch
AT ulainqurrat covid19highlightsthemodeldilemmainbiomedicalresearch
AT hockeandreaschristian covid19highlightsthemodeldilemmainbiomedicalresearch
AT hedtrichsarah covid19highlightsthemodeldilemmainbiomedicalresearch

Ejemplares similares