Cargando…

Lidocaine suppresses the malignant behavior of gastric cancer cells via the c-Met/c-Src pathway

The present study was designed to investigate the role and mechanism of action behind the action of lidocaine in gastric cancer cells. Lidocaine was tested for its potential role in affecting the viability of cells using Cell Counting Kit-8 (CCK-8) assays. It was found that there was a decreased MKN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Wei, Xing, Ze Ting, Tan, Mei Yun, Wu, Yan Wen, Zhang, Chun Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967831/ https://www.ncbi.nlm.nih.gov/pubmed/33747163 http://dx.doi.org/10.3892/etm.2021.9868

Ejemplares similares

Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells
por: Park, Chi Hoon, et al.
Publicado: (2016)

Aggregation of lipid rafts activates c-met and c-Src in non-small cell lung cancer cells
por: Zeng, Juan, et al.
Publicado: (2018)

Verticillin A suppresses HGF-induced migration and invasion via repression of the c-Met/FAK/Src pathway in human gastric and cervical cancer cells
por: Lu, Jingxin, et al.
Publicado: (2019)

c-Src Recruitment is Involved in c-MET-Mediated Malignant Behaviour of NT2D1 Non-Seminoma Cells
por: Leonetti, Erica, et al.
Publicado: (2019)

Mitotic Activation of c‐Src Is Suppressed by Csk
por: Ohsato, Yoshiharu, et al.
Publicado: (1994)

Elevated c-Src and c-Yes expression in malignant skin cancers
por: Lee, Jang Hyun, et al.
Publicado: (2010)

Role of c-Src activity in the regulation of gastric cancer cell migration
por: YANG, YUN, et al.
Publicado: (2014)

Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway
por: Chen, Syue-Ting, et al.
Publicado: (2018)

PELP1 Suppression Inhibits Gastric Cancer Through Downregulation of c-Src-PI3K-ERK Pathway
por: Yan, Hongzhu, et al.
Publicado: (2020)

Mucin glycosylating enzyme GALNT2 suppresses malignancy in gastric adenocarcinoma by reducing MET phosphorylation
por: Liu, Shin-Yun, et al.
Publicado: (2016)

Suppression of c-Met-Overexpressing Tumors by a Novel c-Met/CD3 Bispecific Antibody
por: Huang, Lei, et al.
Publicado: (2020)

Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer
por: Yeh, Chen-Yun, et al.
Publicado: (2011)

Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway
por: Li, Ming, et al.
Publicado: (2017)

ASAP2 interrupts c-MET-CIN85 interaction to sustain HGF/c-MET-induced malignant potentials in hepatocellular carcinoma
por: Ma, Xiao-Lu, et al.
Publicado: (2023)

Expressions and clinical significances of c-MET, p-MET and E2f-1 in human gastric carcinoma
por: Wu, Ju-gang, et al.
Publicado: (2014)

c-src structure in human cancers with elevated pp60c-src activity.
por: Wang, P., et al.
Publicado: (1991)

Paeonol Suppresses Chondrosarcoma Metastasis through Up-Regulation of miR-141 by Modulating PKCδ and c-Src Signaling Pathway
por: Horng, Chi-Ting, et al.
Publicado: (2014)

Blockage of ETS homologous factor inhibits the proliferation and invasion of gastric cancer cells through the c-Met pathway
por: Gu, Meng-Li, et al.
Publicado: (2020)

ER-α36-mediated gastric cancer cell proliferation via the c-Src pathway
por: WANG, XUMING, et al.
Publicado: (2013)

c-Met-Specific Chimeric Antigen Receptor T Cells Demonstrate Anti-Tumor Effect in c-Met Positive Gastric Cancer
por: Kang, Chung Hyo, et al.
Publicado: (2021)

C-src Enriched Serum Microvesicles Are Generated in Malignant Plasma Cell Dyscrasia
por: Di Noto, Giuseppe, et al.
Publicado: (2013)

The Role of cMET in Gastric Cancer—A Review of the Literature
por: Van Herpe, Filip, et al.
Publicado: (2023)

PELP1 Suppression Inhibits Colorectal Cancer through c-Src Downregulation
por: Ning, Zhifeng, et al.
Publicado: (2014)

Effects of Lidocaine and Src Inhibition on Metastasis in a Murine Model of Breast Cancer Surgery
por: Wall, Thomas P., et al.
Publicado: (2019)

MET aberrations and c-MET inhibitors in patients with gastric and esophageal cancers in a phase I unit
por: Jardim, Denis L. Fontes, et al.
Publicado: (2014)

Crizotinib‐based proteolysis targeting chimera suppresses gastric cancer by promoting MET degradation
por: Chen, Jin‐Jiao, et al.
Publicado: (2023)

A c-Met Inhibitor Suppresses Osteosarcoma Progression via the ERK1/2 Pathway in Human Osteosarcoma Cells
por: Chen, Weijie, et al.
Publicado: (2021)

c-Met inhibitors
por: Mughal, Anum, et al.
Publicado: (2013)

Suppression of c-MET overcomes erlotinib resistance in tongue cancer cells
por: Huang, Keqiang, et al.
Publicado: (2018)

MicroRNA-206: Effective Inhibition of Gastric Cancer Progression through the c-Met Pathway
por: Zheng, Zhiqiang, et al.
Publicado: (2015)

Expression of c-MET in Invasive Meningioma
por: Yun, Sumi, et al.
Publicado: (2015)

RANKL/RANK pathway abrogates cetuximab sensitivity in gastric cancer cells via activation of EGFR and c-Src
por: Zhang, Xiaomeng, et al.
Publicado: (2017)

IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis
por: Chu, Pei-Yi, et al.
Publicado: (2022)

The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signaling
por: Booth, Laurence, et al.
Publicado: (2016)

Crosstalk Mechanisms Between HGF/c-Met Axis and ncRNAs in Malignancy
por: Liu, Xin, et al.
Publicado: (2020)

Regulation of cytochrome c oxidase activity by c-Src in osteoclasts
por: Miyazaki, Tsuyoshi, et al.
Publicado: (2003)

Exosome-Delivered c-Met siRNA Could Reverse Chemoresistance to Cisplatin in Gastric Cancer
por: Zhang, Qiumo, et al.
Publicado: (2020)

Silencing of LncRNA C1RL-AS1 Suppresses the Malignant Phenotype in Gastric Cancer Cells via the AKT/β-Catenin/c-Myc Pathway
por: Zhen-Hua, Wu, et al.
Publicado: (2020)

MiR-34c suppresses tumor growth and metastasis in nasopharyngeal carcinoma by targeting MET
por: Li, Y-Q, et al.
Publicado: (2015)

4‐phenylpyridine suppresses UVB‐induced skin inflammation by targeting c‐Src in vitro and in vivo
por: Kim, Ju Gyeong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_n0ns9c8ocd71le0ftp2b848rln