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Meta-analysis of laboratory results in patients with severe coronavirus disease 2019
The aim of the present study was to analyze the differences in laboratory results between patients with severe and moderate coronavirus disease 2019 (COVID-19) for clinical intervention. The laboratory results of patients with COVID-19 between December 2019 and May 2020 were assembled from the Medli...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967851/ https://www.ncbi.nlm.nih.gov/pubmed/33747184 http://dx.doi.org/10.3892/etm.2021.9877 |
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author | Huang, Yun Zhang, Yuyu Ma, Lili |
author_facet | Huang, Yun Zhang, Yuyu Ma, Lili |
author_sort | Huang, Yun |
collection | PubMed |
description | The aim of the present study was to analyze the differences in laboratory results between patients with severe and moderate coronavirus disease 2019 (COVID-19) for clinical intervention. The laboratory results of patients with COVID-19 between December 2019 and May 2020 were assembled from the Medline, Embase and Cochrane Library databases. A meta-analysis was conducted, calculating the individual and pooled odds ratios (ORs) with relative 95% confidence intervals (95% CIs) using Review Manager 5.3. The available data of 1,534 patients from 6 studies were included in this analysis. The results demonstrated that the incidence of leukocytosis, lymphocytopenia, increased procalcitonin (PCT), C-reactive protein (CRP), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) levels was associated with a nearly 3-fold (OR=3.44; 95% CI: 2.15-5.49), 4-fold (OR=4.39; 95% CI: 1.82-10.60), 5-fold (OR=5.28; 95% CI: 3.42-8.15), 4-fold (OR=3.99; 95% CI: 2.61-6.12), 3-fold (OR=3.02; 95% CI: 2.13-4.26) and 8-fold (OR=8.33; 95% CI: 1.75-39.69) higher risk of severe COVID-19 infection, respectively. These findings indicated that serial white blood cell count, lymphocyte count, CRP, PCT, LDH and AST measurements may be useful for predicting progression towards a more severe form of COVID-19. |
format | Online Article Text |
id | pubmed-7967851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-79678512021-03-19 Meta-analysis of laboratory results in patients with severe coronavirus disease 2019 Huang, Yun Zhang, Yuyu Ma, Lili Exp Ther Med Articles The aim of the present study was to analyze the differences in laboratory results between patients with severe and moderate coronavirus disease 2019 (COVID-19) for clinical intervention. The laboratory results of patients with COVID-19 between December 2019 and May 2020 were assembled from the Medline, Embase and Cochrane Library databases. A meta-analysis was conducted, calculating the individual and pooled odds ratios (ORs) with relative 95% confidence intervals (95% CIs) using Review Manager 5.3. The available data of 1,534 patients from 6 studies were included in this analysis. The results demonstrated that the incidence of leukocytosis, lymphocytopenia, increased procalcitonin (PCT), C-reactive protein (CRP), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) levels was associated with a nearly 3-fold (OR=3.44; 95% CI: 2.15-5.49), 4-fold (OR=4.39; 95% CI: 1.82-10.60), 5-fold (OR=5.28; 95% CI: 3.42-8.15), 4-fold (OR=3.99; 95% CI: 2.61-6.12), 3-fold (OR=3.02; 95% CI: 2.13-4.26) and 8-fold (OR=8.33; 95% CI: 1.75-39.69) higher risk of severe COVID-19 infection, respectively. These findings indicated that serial white blood cell count, lymphocyte count, CRP, PCT, LDH and AST measurements may be useful for predicting progression towards a more severe form of COVID-19. D.A. Spandidos 2021-05 2021-03-01 /pmc/articles/PMC7967851/ /pubmed/33747184 http://dx.doi.org/10.3892/etm.2021.9877 Text en Copyright: © Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Huang, Yun Zhang, Yuyu Ma, Lili Meta-analysis of laboratory results in patients with severe coronavirus disease 2019 |
title | Meta-analysis of laboratory results in patients with severe coronavirus disease 2019 |
title_full | Meta-analysis of laboratory results in patients with severe coronavirus disease 2019 |
title_fullStr | Meta-analysis of laboratory results in patients with severe coronavirus disease 2019 |
title_full_unstemmed | Meta-analysis of laboratory results in patients with severe coronavirus disease 2019 |
title_short | Meta-analysis of laboratory results in patients with severe coronavirus disease 2019 |
title_sort | meta-analysis of laboratory results in patients with severe coronavirus disease 2019 |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967851/ https://www.ncbi.nlm.nih.gov/pubmed/33747184 http://dx.doi.org/10.3892/etm.2021.9877 |
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