Cargando…

Meta-analysis of laboratory results in patients with severe coronavirus disease 2019

The aim of the present study was to analyze the differences in laboratory results between patients with severe and moderate coronavirus disease 2019 (COVID-19) for clinical intervention. The laboratory results of patients with COVID-19 between December 2019 and May 2020 were assembled from the Medli...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Yun, Zhang, Yuyu, Ma, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967851/
https://www.ncbi.nlm.nih.gov/pubmed/33747184
http://dx.doi.org/10.3892/etm.2021.9877
_version_ 1783665962357096448
author Huang, Yun
Zhang, Yuyu
Ma, Lili
author_facet Huang, Yun
Zhang, Yuyu
Ma, Lili
author_sort Huang, Yun
collection PubMed
description The aim of the present study was to analyze the differences in laboratory results between patients with severe and moderate coronavirus disease 2019 (COVID-19) for clinical intervention. The laboratory results of patients with COVID-19 between December 2019 and May 2020 were assembled from the Medline, Embase and Cochrane Library databases. A meta-analysis was conducted, calculating the individual and pooled odds ratios (ORs) with relative 95% confidence intervals (95% CIs) using Review Manager 5.3. The available data of 1,534 patients from 6 studies were included in this analysis. The results demonstrated that the incidence of leukocytosis, lymphocytopenia, increased procalcitonin (PCT), C-reactive protein (CRP), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) levels was associated with a nearly 3-fold (OR=3.44; 95% CI: 2.15-5.49), 4-fold (OR=4.39; 95% CI: 1.82-10.60), 5-fold (OR=5.28; 95% CI: 3.42-8.15), 4-fold (OR=3.99; 95% CI: 2.61-6.12), 3-fold (OR=3.02; 95% CI: 2.13-4.26) and 8-fold (OR=8.33; 95% CI: 1.75-39.69) higher risk of severe COVID-19 infection, respectively. These findings indicated that serial white blood cell count, lymphocyte count, CRP, PCT, LDH and AST measurements may be useful for predicting progression towards a more severe form of COVID-19.
format Online
Article
Text
id pubmed-7967851
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-79678512021-03-19 Meta-analysis of laboratory results in patients with severe coronavirus disease 2019 Huang, Yun Zhang, Yuyu Ma, Lili Exp Ther Med Articles The aim of the present study was to analyze the differences in laboratory results between patients with severe and moderate coronavirus disease 2019 (COVID-19) for clinical intervention. The laboratory results of patients with COVID-19 between December 2019 and May 2020 were assembled from the Medline, Embase and Cochrane Library databases. A meta-analysis was conducted, calculating the individual and pooled odds ratios (ORs) with relative 95% confidence intervals (95% CIs) using Review Manager 5.3. The available data of 1,534 patients from 6 studies were included in this analysis. The results demonstrated that the incidence of leukocytosis, lymphocytopenia, increased procalcitonin (PCT), C-reactive protein (CRP), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) levels was associated with a nearly 3-fold (OR=3.44; 95% CI: 2.15-5.49), 4-fold (OR=4.39; 95% CI: 1.82-10.60), 5-fold (OR=5.28; 95% CI: 3.42-8.15), 4-fold (OR=3.99; 95% CI: 2.61-6.12), 3-fold (OR=3.02; 95% CI: 2.13-4.26) and 8-fold (OR=8.33; 95% CI: 1.75-39.69) higher risk of severe COVID-19 infection, respectively. These findings indicated that serial white blood cell count, lymphocyte count, CRP, PCT, LDH and AST measurements may be useful for predicting progression towards a more severe form of COVID-19. D.A. Spandidos 2021-05 2021-03-01 /pmc/articles/PMC7967851/ /pubmed/33747184 http://dx.doi.org/10.3892/etm.2021.9877 Text en Copyright: © Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Huang, Yun
Zhang, Yuyu
Ma, Lili
Meta-analysis of laboratory results in patients with severe coronavirus disease 2019
title Meta-analysis of laboratory results in patients with severe coronavirus disease 2019
title_full Meta-analysis of laboratory results in patients with severe coronavirus disease 2019
title_fullStr Meta-analysis of laboratory results in patients with severe coronavirus disease 2019
title_full_unstemmed Meta-analysis of laboratory results in patients with severe coronavirus disease 2019
title_short Meta-analysis of laboratory results in patients with severe coronavirus disease 2019
title_sort meta-analysis of laboratory results in patients with severe coronavirus disease 2019
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967851/
https://www.ncbi.nlm.nih.gov/pubmed/33747184
http://dx.doi.org/10.3892/etm.2021.9877
work_keys_str_mv AT huangyun metaanalysisoflaboratoryresultsinpatientswithseverecoronavirusdisease2019
AT zhangyuyu metaanalysisoflaboratoryresultsinpatientswithseverecoronavirusdisease2019
AT malili metaanalysisoflaboratoryresultsinpatientswithseverecoronavirusdisease2019