Decitabine inhibits the proliferation of human T-cell acute lymphoblastic leukemia molt4 cells and promotes apoptosis partly by regulating the PI3K/AKT/mTOR pathway

T cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematological cancer; however, there is a lack of effective chemotherapeutic or targeted drugs for the treatment of T-ALL. Decitabine is a DNA demethylation agent but it has not been used for T-ALL treatment. Therefore, the present s...

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Detalles Bibliográficos
Autores principales: Zhang, Gang, Gao, Xiaohui, Zhao, Xiaoyan, Wu, Haibing, Yan, Minchao, Li, Yuan, Zeng, Hui, Ji, Zhaoning, Guo, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967925/
https://www.ncbi.nlm.nih.gov/pubmed/33747197
http://dx.doi.org/10.3892/ol.2021.12601

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