Pathway size matters: the influence of pathway granularity on over-representation (enrichment analysis) statistics

BACKGROUND: Enrichment or over-representation analysis is a common method used in bioinformatics studies of transcriptomics, metabolomics, and microbiome datasets. The key idea behind enrichment analysis is: given a set of significantly expressed genes (or metabolites), use that set to infer a small...

Descripción completa

Detalles Bibliográficos
Autores principales: Karp, Peter D., Midford, Peter E., Caspi, Ron, Khodursky, Arkady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967953/
https://www.ncbi.nlm.nih.gov/pubmed/33726670
http://dx.doi.org/10.1186/s12864-021-07502-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967953/
https://www.ncbi.nlm.nih.gov/pubmed/33726670
http://dx.doi.org/10.1186/s12864-021-07502-8

Ejemplares similares