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Pathway size matters: the influence of pathway granularity on over-representation (enrichment analysis) statistics

BACKGROUND: Enrichment or over-representation analysis is a common method used in bioinformatics studies of transcriptomics, metabolomics, and microbiome datasets. The key idea behind enrichment analysis is: given a set of significantly expressed genes (or metabolites), use that set to infer a small...

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Detalles Bibliográficos
Autores principales:	Karp, Peter D., Midford, Peter E., Caspi, Ron, Khodursky, Arkady
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967953/ https://www.ncbi.nlm.nih.gov/pubmed/33726670 http://dx.doi.org/10.1186/s12864-021-07502-8

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