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Gallbladder adenoma in a domestic shorthair cat

A 13-year-old neutered female domestic shorthair rescue cat presented asymptomatically with raised hepatic enzymes following a routine pre-anaesthetic blood test. Cholangitis was suspected, and supportive treatment with 2 weeks of amoxicillin–clavulanic acid and 4 weeks of ursodeoxycholic acid and S...

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Autores principales: Broadbridge, Catherine, Taylor, Samantha S, Renfrew, Helen, Gemignani, Francesco, Livet, Veronique, Vicek, Tom, Dobromylskyj, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968027/
https://www.ncbi.nlm.nih.gov/pubmed/33796327
http://dx.doi.org/10.1177/2055116921997665
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author Broadbridge, Catherine
Taylor, Samantha S
Renfrew, Helen
Gemignani, Francesco
Livet, Veronique
Vicek, Tom
Dobromylskyj, Melanie
author_facet Broadbridge, Catherine
Taylor, Samantha S
Renfrew, Helen
Gemignani, Francesco
Livet, Veronique
Vicek, Tom
Dobromylskyj, Melanie
author_sort Broadbridge, Catherine
collection PubMed
description A 13-year-old neutered female domestic shorthair rescue cat presented asymptomatically with raised hepatic enzymes following a routine pre-anaesthetic blood test. Cholangitis was suspected, and supportive treatment with 2 weeks of amoxicillin–clavulanic acid and 4 weeks of ursodeoxycholic acid and S-adenosylmethionine was trialled, with no improvement in biochemistry parameters. Clinicopathological investigations also revealed a markedly raised total bilirubin and abnormal bile acid stimulation test. Abdominal ultrasonography revealed pathological changes in the gallbladder, hepatomegaly with increased echogenicity and markedly thickened common bile duct walls. An exploratory laparotomy was performed revealing a grossly abnormal gallbladder with a small rupture at the dorsal fundus, which was managed via cholecystectomy. Pancreatic and hepatic biopsies were collected concurrently. Histopathology from the submitted samples revealed a gallbladder adenoma, chronic neutrophilic cholangitis and nodular hyperplasia of the pancreas. Culture of the gallbladder bile was negative but may be attributable to the initial treatment with antibiosis. At the time of writing, 5 months postoperatively, the cat had recovered well and remained asymptomatic and clinically healthy, but hepatic enzymes and bilirubin were only mildly reduced from the preoperative levels, despite the cat remaining clinically normal. RELEVANCE AND NOVEL INFORMATION: To our knowledge, this is the first case of a gallbladder adenoma confirmed histopathologically in a feline patient. Our findings suggest that although gallbladder neoplasia is rare in cats, this benign tumour should be considered a differential diagnosis.
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spelling pubmed-79680272021-03-31 Gallbladder adenoma in a domestic shorthair cat Broadbridge, Catherine Taylor, Samantha S Renfrew, Helen Gemignani, Francesco Livet, Veronique Vicek, Tom Dobromylskyj, Melanie JFMS Open Rep Case Report A 13-year-old neutered female domestic shorthair rescue cat presented asymptomatically with raised hepatic enzymes following a routine pre-anaesthetic blood test. Cholangitis was suspected, and supportive treatment with 2 weeks of amoxicillin–clavulanic acid and 4 weeks of ursodeoxycholic acid and S-adenosylmethionine was trialled, with no improvement in biochemistry parameters. Clinicopathological investigations also revealed a markedly raised total bilirubin and abnormal bile acid stimulation test. Abdominal ultrasonography revealed pathological changes in the gallbladder, hepatomegaly with increased echogenicity and markedly thickened common bile duct walls. An exploratory laparotomy was performed revealing a grossly abnormal gallbladder with a small rupture at the dorsal fundus, which was managed via cholecystectomy. Pancreatic and hepatic biopsies were collected concurrently. Histopathology from the submitted samples revealed a gallbladder adenoma, chronic neutrophilic cholangitis and nodular hyperplasia of the pancreas. Culture of the gallbladder bile was negative but may be attributable to the initial treatment with antibiosis. At the time of writing, 5 months postoperatively, the cat had recovered well and remained asymptomatic and clinically healthy, but hepatic enzymes and bilirubin were only mildly reduced from the preoperative levels, despite the cat remaining clinically normal. RELEVANCE AND NOVEL INFORMATION: To our knowledge, this is the first case of a gallbladder adenoma confirmed histopathologically in a feline patient. Our findings suggest that although gallbladder neoplasia is rare in cats, this benign tumour should be considered a differential diagnosis. SAGE Publications 2021-03-14 /pmc/articles/PMC7968027/ /pubmed/33796327 http://dx.doi.org/10.1177/2055116921997665 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Broadbridge, Catherine
Taylor, Samantha S
Renfrew, Helen
Gemignani, Francesco
Livet, Veronique
Vicek, Tom
Dobromylskyj, Melanie
Gallbladder adenoma in a domestic shorthair cat
title Gallbladder adenoma in a domestic shorthair cat
title_full Gallbladder adenoma in a domestic shorthair cat
title_fullStr Gallbladder adenoma in a domestic shorthair cat
title_full_unstemmed Gallbladder adenoma in a domestic shorthair cat
title_short Gallbladder adenoma in a domestic shorthair cat
title_sort gallbladder adenoma in a domestic shorthair cat
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968027/
https://www.ncbi.nlm.nih.gov/pubmed/33796327
http://dx.doi.org/10.1177/2055116921997665
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