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Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, in vitro 2D/3D human lung cell cultures, and in vivo efficacy

Inhalable nanostructured microparticles of simvastatin, a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor, were rationally designed for targeted pulmonary delivery as dry powder inhalers (DPIs) for the treatment of pulmonary hypertension (PH). Advanced particle engineering design technology was...

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Detalles Bibliográficos
Autores principales:	Acosta, Maria F., Muralidharan, Priya, Grijalva, Carissa L., Abrahamson, Michael D., Hayes, Don, Fineman, Jeffrey R., Black, Stephen M., Mansour, Heidi M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968029/ https://www.ncbi.nlm.nih.gov/pubmed/33719747 http://dx.doi.org/10.1177/1753466621998245

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