Retrospective serosurveillance for anti-SARS-CoV-2 immunoglobulin during a time of low prevalence: A cautionary tale

We performed a retrospective screening of 428 serum samples for anti-SARS-CoV-2  immunoglobulin during a period of low prevalence. Employing two different serological tests yielded discrepant results for 10 samples; highlighting an increased risk of potential  false positive results and the need for...

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Autores principales: Bird, Paul William, Holmes, Christopher, Fletcher, Oliver, Badhwar, Vinay, Toovey, Oliver, Tang, Julian Wei-Tze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd on behalf of The British Infection Association. 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968146/
https://www.ncbi.nlm.nih.gov/pubmed/33744303
http://dx.doi.org/10.1016/j.jinf.2021.03.007
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author Bird, Paul William
Holmes, Christopher
Fletcher, Oliver
Badhwar, Vinay
Toovey, Oliver
Tang, Julian Wei-Tze
author_facet Bird, Paul William
Holmes, Christopher
Fletcher, Oliver
Badhwar, Vinay
Toovey, Oliver
Tang, Julian Wei-Tze
author_sort Bird, Paul William
collection PubMed
description We performed a retrospective screening of 428 serum samples for anti-SARS-CoV-2  immunoglobulin during a period of low prevalence. Employing two different serological tests yielded discrepant results for 10 samples; highlighting an increased risk of potential  false positive results and the need for further confirmatory testing before publication of data.
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spelling pubmed-79681462021-03-17 Retrospective serosurveillance for anti-SARS-CoV-2 immunoglobulin during a time of low prevalence: A cautionary tale Bird, Paul William Holmes, Christopher Fletcher, Oliver Badhwar, Vinay Toovey, Oliver Tang, Julian Wei-Tze J Infect Letter to the Editor We performed a retrospective screening of 428 serum samples for anti-SARS-CoV-2  immunoglobulin during a period of low prevalence. Employing two different serological tests yielded discrepant results for 10 samples; highlighting an increased risk of potential  false positive results and the need for further confirmatory testing before publication of data. Published by Elsevier Ltd on behalf of The British Infection Association. 2021-07 2021-03-17 /pmc/articles/PMC7968146/ /pubmed/33744303 http://dx.doi.org/10.1016/j.jinf.2021.03.007 Text en Crown Copyright © 2021 Published by Elsevier Ltd on behalf of The British Infection Association. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Letter to the Editor
Bird, Paul William
Holmes, Christopher
Fletcher, Oliver
Badhwar, Vinay
Toovey, Oliver
Tang, Julian Wei-Tze
Retrospective serosurveillance for anti-SARS-CoV-2 immunoglobulin during a time of low prevalence: A cautionary tale
title Retrospective serosurveillance for anti-SARS-CoV-2 immunoglobulin during a time of low prevalence: A cautionary tale
title_full Retrospective serosurveillance for anti-SARS-CoV-2 immunoglobulin during a time of low prevalence: A cautionary tale
title_fullStr Retrospective serosurveillance for anti-SARS-CoV-2 immunoglobulin during a time of low prevalence: A cautionary tale
title_full_unstemmed Retrospective serosurveillance for anti-SARS-CoV-2 immunoglobulin during a time of low prevalence: A cautionary tale
title_short Retrospective serosurveillance for anti-SARS-CoV-2 immunoglobulin during a time of low prevalence: A cautionary tale
title_sort retrospective serosurveillance for anti-sars-cov-2 immunoglobulin during a time of low prevalence: a cautionary tale
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968146/
https://www.ncbi.nlm.nih.gov/pubmed/33744303
http://dx.doi.org/10.1016/j.jinf.2021.03.007
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