Does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas?

AIM: Sarcomatoid carcinoma of the pancreas (SCP) is an extremely rare and aggressive disease with poor prognosis. We have already reported a rare case of SCP with long-term survival. In the present article, we investigate the underlying mechanisms of patient’s long-term survival from the point of vi...

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Autores principales: Kimura, Toshihisa, Togawa, Tamotsu, Iida, Atsushi, Noriki, Sakon, Sato, Yasunori, Goi, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968209/
https://www.ncbi.nlm.nih.gov/pubmed/33726729
http://dx.doi.org/10.1186/s12957-021-02177-7
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author Kimura, Toshihisa
Togawa, Tamotsu
Iida, Atsushi
Noriki, Sakon
Sato, Yasunori
Goi, Takanori
author_facet Kimura, Toshihisa
Togawa, Tamotsu
Iida, Atsushi
Noriki, Sakon
Sato, Yasunori
Goi, Takanori
author_sort Kimura, Toshihisa
collection PubMed
description AIM: Sarcomatoid carcinoma of the pancreas (SCP) is an extremely rare and aggressive disease with poor prognosis. We have already reported a rare case of SCP with long-term survival. In the present article, we investigate the underlying mechanisms of patient’s long-term survival from the point of view of cellular senescence which was examined in three SCP cases, including our reported case, using immunohistochemical analysis. FINDINGS: The expressions of cellular senescence marker were observed in the sarcomatous component of the patient with long-term survival but not observed in the other patients with short- term survival. Thus, we can speculate that cellular senescence might play an important role in the reduction of the cell proliferative and metastatic activities of sarcomatous cells, leading to long-term patient survival.
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spelling pubmed-79682092021-03-22 Does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas? Kimura, Toshihisa Togawa, Tamotsu Iida, Atsushi Noriki, Sakon Sato, Yasunori Goi, Takanori World J Surg Oncol Correspondence AIM: Sarcomatoid carcinoma of the pancreas (SCP) is an extremely rare and aggressive disease with poor prognosis. We have already reported a rare case of SCP with long-term survival. In the present article, we investigate the underlying mechanisms of patient’s long-term survival from the point of view of cellular senescence which was examined in three SCP cases, including our reported case, using immunohistochemical analysis. FINDINGS: The expressions of cellular senescence marker were observed in the sarcomatous component of the patient with long-term survival but not observed in the other patients with short- term survival. Thus, we can speculate that cellular senescence might play an important role in the reduction of the cell proliferative and metastatic activities of sarcomatous cells, leading to long-term patient survival. BioMed Central 2021-03-16 /pmc/articles/PMC7968209/ /pubmed/33726729 http://dx.doi.org/10.1186/s12957-021-02177-7 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Correspondence
Kimura, Toshihisa
Togawa, Tamotsu
Iida, Atsushi
Noriki, Sakon
Sato, Yasunori
Goi, Takanori
Does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas?
title Does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas?
title_full Does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas?
title_fullStr Does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas?
title_full_unstemmed Does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas?
title_short Does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas?
title_sort does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas?
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968209/
https://www.ncbi.nlm.nih.gov/pubmed/33726729
http://dx.doi.org/10.1186/s12957-021-02177-7
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