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Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor

Inositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell survival. During conditions of irrevocable stress, proapoptotic gene expression is induced to p...

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Detalles Bibliográficos
Autores principales:	Bartoszewska, Sylwia, Króliczewski, Jarosław, Crossman, David K., Pogorzelska, Aneta, Bagiński, Maciej, Collawn, James F., Bartoszewski, Rafal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968329/ https://www.ncbi.nlm.nih.gov/pubmed/33730996 http://dx.doi.org/10.1186/s11658-021-00255-y

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