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Relation between carotid intima media thickness and oxidative stress markers in type 1 diabetic children and adolescents

BACKGROUND: Carotid intima media thickness (CIMT) is a non invasive marker of subclinical atherosclerosis. Hyperglycemia, oxidatively modified atherogenic lipoproteins and advanced glycation end products are linked to increased oxidative stress in diabetes. We aimed to find out the relation between...

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Autores principales: El Samahy, Mona H, Matter, Randa M, Youssef, Omneya I, Shams El Din El Telbany, Manal A, Kamal, Nermeen A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968341/
https://www.ncbi.nlm.nih.gov/pubmed/24355617
http://dx.doi.org/10.1186/2251-6581-12-50
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author El Samahy, Mona H
Matter, Randa M
Youssef, Omneya I
Shams El Din El Telbany, Manal A
Kamal, Nermeen A
author_facet El Samahy, Mona H
Matter, Randa M
Youssef, Omneya I
Shams El Din El Telbany, Manal A
Kamal, Nermeen A
author_sort El Samahy, Mona H
collection PubMed
description BACKGROUND: Carotid intima media thickness (CIMT) is a non invasive marker of subclinical atherosclerosis. Hyperglycemia, oxidatively modified atherogenic lipoproteins and advanced glycation end products are linked to increased oxidative stress in diabetes. We aimed to find out the relation between carotid intima media thickness in type 1 diabetic children and adolescents and plasma nitric oxide and total antioxidant capacity levels as markers of oxidative stress. METHODS: This study included 50 children and adolescents with type 1 diabetes mellitus with mean age (9.7 ± 3.4 years) and 50 healthy age and sex matched controls. They were subjected to assessment of hemoglobin A1c, total cholesterol and triglycerides, serum total antioxidant capacity, serum nitric oxide (NO) by colorimetric method and carotid intima media thickness by B-mode ultrasound. RESULTS: There was significant elevation in serum nitric oxide (17.07 ± 6.4 vs 12.6 ± 4.7 μmol/L; p < 0.001), CIMT (0.47 ± 0.04 vs 0.39 ± 0.02 mm; p < 0.001) and significant reduction in serum total antioxidant capacity (0.41 ± 0.29 vs 0.87 ± 0.23 mmol/L; p < 0.001) in diabetic patients compared to controls. Carotid intima media thickness was correlated positively with nitric oxide (r = 0.402, p = 0.01) and negatively with total antioxidant capacity (r = -0.341, p = 0.02). Carotid intima media thickness was also correlated positively with age, duration of diabetes but not correlated with glycemic control or lipid profile. CONCLUSION: The significant elevation in nitric oxide and reduction in total antioxidant capacity in children and adolescents with type 1 diabetes mellitus with their correlation with carotid intima media thickness may reflect the role of oxidative stress in the development of atherosclerosis in young type 1 diabetic subjects. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2251-6581-12-50) contains supplementary material, which is available to authorized users.
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spelling pubmed-79683412021-04-01 Relation between carotid intima media thickness and oxidative stress markers in type 1 diabetic children and adolescents El Samahy, Mona H Matter, Randa M Youssef, Omneya I Shams El Din El Telbany, Manal A Kamal, Nermeen A J Diabetes Metab Disord Research Article BACKGROUND: Carotid intima media thickness (CIMT) is a non invasive marker of subclinical atherosclerosis. Hyperglycemia, oxidatively modified atherogenic lipoproteins and advanced glycation end products are linked to increased oxidative stress in diabetes. We aimed to find out the relation between carotid intima media thickness in type 1 diabetic children and adolescents and plasma nitric oxide and total antioxidant capacity levels as markers of oxidative stress. METHODS: This study included 50 children and adolescents with type 1 diabetes mellitus with mean age (9.7 ± 3.4 years) and 50 healthy age and sex matched controls. They were subjected to assessment of hemoglobin A1c, total cholesterol and triglycerides, serum total antioxidant capacity, serum nitric oxide (NO) by colorimetric method and carotid intima media thickness by B-mode ultrasound. RESULTS: There was significant elevation in serum nitric oxide (17.07 ± 6.4 vs 12.6 ± 4.7 μmol/L; p < 0.001), CIMT (0.47 ± 0.04 vs 0.39 ± 0.02 mm; p < 0.001) and significant reduction in serum total antioxidant capacity (0.41 ± 0.29 vs 0.87 ± 0.23 mmol/L; p < 0.001) in diabetic patients compared to controls. Carotid intima media thickness was correlated positively with nitric oxide (r = 0.402, p = 0.01) and negatively with total antioxidant capacity (r = -0.341, p = 0.02). Carotid intima media thickness was also correlated positively with age, duration of diabetes but not correlated with glycemic control or lipid profile. CONCLUSION: The significant elevation in nitric oxide and reduction in total antioxidant capacity in children and adolescents with type 1 diabetes mellitus with their correlation with carotid intima media thickness may reflect the role of oxidative stress in the development of atherosclerosis in young type 1 diabetic subjects. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2251-6581-12-50) contains supplementary material, which is available to authorized users. BioMed Central 2013-12-19 /pmc/articles/PMC7968341/ /pubmed/24355617 http://dx.doi.org/10.1186/2251-6581-12-50 Text en © El Samahy et al.; licensee BioMed Central Ltd. 2013 http://creativecommons.org/licenses/by/2.0 This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
El Samahy, Mona H
Matter, Randa M
Youssef, Omneya I
Shams El Din El Telbany, Manal A
Kamal, Nermeen A
Relation between carotid intima media thickness and oxidative stress markers in type 1 diabetic children and adolescents
title Relation between carotid intima media thickness and oxidative stress markers in type 1 diabetic children and adolescents
title_full Relation between carotid intima media thickness and oxidative stress markers in type 1 diabetic children and adolescents
title_fullStr Relation between carotid intima media thickness and oxidative stress markers in type 1 diabetic children and adolescents
title_full_unstemmed Relation between carotid intima media thickness and oxidative stress markers in type 1 diabetic children and adolescents
title_short Relation between carotid intima media thickness and oxidative stress markers in type 1 diabetic children and adolescents
title_sort relation between carotid intima media thickness and oxidative stress markers in type 1 diabetic children and adolescents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968341/
https://www.ncbi.nlm.nih.gov/pubmed/24355617
http://dx.doi.org/10.1186/2251-6581-12-50
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