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Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China

The purpose of this study was to assess the relationship between 25-hydroxyvitamin D (25(OH)D), urinary iodine concentration (UIC), and type 2 diabetes mellitus (T2DM) risk and complications and to establish a model to predict T2DM in the general population. A total of 567 adults (389 T2DM patients...

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Autores principales: Zhuo, Yafen, Ling, Lin, Sun, Zhichun, Huang, Wensen, Hong, Zhenzhen, Zhang, Yaping, Peng, Xuefeng, Liu, Xiaoyu, Yuan, Weilan, Xu, Wang-Yang, Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968538/
https://www.ncbi.nlm.nih.gov/pubmed/33817307
http://dx.doi.org/10.1515/biol-2021-0019
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author Zhuo, Yafen
Ling, Lin
Sun, Zhichun
Huang, Wensen
Hong, Zhenzhen
Zhang, Yaping
Peng, Xuefeng
Liu, Xiaoyu
Yuan, Weilan
Xu, Wang-Yang
Zhang, Yi
author_facet Zhuo, Yafen
Ling, Lin
Sun, Zhichun
Huang, Wensen
Hong, Zhenzhen
Zhang, Yaping
Peng, Xuefeng
Liu, Xiaoyu
Yuan, Weilan
Xu, Wang-Yang
Zhang, Yi
author_sort Zhuo, Yafen
collection PubMed
description The purpose of this study was to assess the relationship between 25-hydroxyvitamin D (25(OH)D), urinary iodine concentration (UIC), and type 2 diabetes mellitus (T2DM) risk and complications and to establish a model to predict T2DM in the general population. A total of 567 adults (389 T2DM patients and 178 controls) were enrolled, and the levels of 25(OH)D, iodine, and blood biochemical parameters were measured. Pearson’s correlation analysis showed an inverse correlation between 25(OH)D level, UIC, and T2DM risk. Low 25(OH)D level was a risk factor for developing T2DM (OR, 0.81; 95% CI, 1.90–2.63; P = 0.043) after adjustment for multiple risk factors. 25(OH)D level and UIC were inversely correlated with short-term and long-term glucose levels. 25(OH)D deficiency was also associated with a high incidence of T2DM complicated with thyroid dysfunction. A prediction model based on 25(OH)D, iodine status, and other risk factors was established and recommended to screen high-risk T2DM in the general population and provide early screening and timely treatment for them.
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spelling pubmed-79685382021-04-01 Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China Zhuo, Yafen Ling, Lin Sun, Zhichun Huang, Wensen Hong, Zhenzhen Zhang, Yaping Peng, Xuefeng Liu, Xiaoyu Yuan, Weilan Xu, Wang-Yang Zhang, Yi Open Life Sci Research Article The purpose of this study was to assess the relationship between 25-hydroxyvitamin D (25(OH)D), urinary iodine concentration (UIC), and type 2 diabetes mellitus (T2DM) risk and complications and to establish a model to predict T2DM in the general population. A total of 567 adults (389 T2DM patients and 178 controls) were enrolled, and the levels of 25(OH)D, iodine, and blood biochemical parameters were measured. Pearson’s correlation analysis showed an inverse correlation between 25(OH)D level, UIC, and T2DM risk. Low 25(OH)D level was a risk factor for developing T2DM (OR, 0.81; 95% CI, 1.90–2.63; P = 0.043) after adjustment for multiple risk factors. 25(OH)D level and UIC were inversely correlated with short-term and long-term glucose levels. 25(OH)D deficiency was also associated with a high incidence of T2DM complicated with thyroid dysfunction. A prediction model based on 25(OH)D, iodine status, and other risk factors was established and recommended to screen high-risk T2DM in the general population and provide early screening and timely treatment for them. De Gruyter 2021-02-18 /pmc/articles/PMC7968538/ /pubmed/33817307 http://dx.doi.org/10.1515/biol-2021-0019 Text en © 2021 Yafen Zhuo et al., published by De Gruyter http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
Zhuo, Yafen
Ling, Lin
Sun, Zhichun
Huang, Wensen
Hong, Zhenzhen
Zhang, Yaping
Peng, Xuefeng
Liu, Xiaoyu
Yuan, Weilan
Xu, Wang-Yang
Zhang, Yi
Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
title Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
title_full Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
title_fullStr Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
title_full_unstemmed Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
title_short Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
title_sort vitamin d and iodine status was associated with the risk and complication of type 2 diabetes mellitus in china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968538/
https://www.ncbi.nlm.nih.gov/pubmed/33817307
http://dx.doi.org/10.1515/biol-2021-0019
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