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Pleiotrope Wirkung von Vitamin D mit Berücksichtigung von COVID-19
Vitamin D is provided by nutritional sources or by skin synthesis under the influence of UV light. In the liver, vitamin D is converted to 25(OH)-vitamin D and finally in the kidney to 1,25(OH)2-vitamin D, which is a hormone regulating bone and mineral metabolism. Besides the kidneys, other organs a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Vienna
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968561/ http://dx.doi.org/10.1007/s41970-021-00146-w |
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author | Scharla, Stephan H. |
author_facet | Scharla, Stephan H. |
author_sort | Scharla, Stephan H. |
collection | PubMed |
description | Vitamin D is provided by nutritional sources or by skin synthesis under the influence of UV light. In the liver, vitamin D is converted to 25(OH)-vitamin D and finally in the kidney to 1,25(OH)2-vitamin D, which is a hormone regulating bone and mineral metabolism. Besides the kidneys, other organs are also capable of making 1,25(OH)2-vitamin D, which exerts autocrine and paracrine effects. For these pleiotropic effects, a continuous vitamin D supply (daily supplements) with moderate doses is more effective than high-dose bolus applications. Beside the classical effects of 1,25(OH)2-vitamin D on the musculoskeletal system, there is good evidence for extraskeletal effects on the immune system. A good vitamin D supply can reduce the risk of respiratory infections. At the present time, the preventive and therapeutic use of vitamin D regarding COVID-19 (coronavirus disease 19) is of great interest. |
format | Online Article Text |
id | pubmed-7968561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-79685612021-03-18 Pleiotrope Wirkung von Vitamin D mit Berücksichtigung von COVID-19 Scharla, Stephan H. J. Miner. Stoffwechs. Muskuloskelet. Erkrank. Originalien Vitamin D is provided by nutritional sources or by skin synthesis under the influence of UV light. In the liver, vitamin D is converted to 25(OH)-vitamin D and finally in the kidney to 1,25(OH)2-vitamin D, which is a hormone regulating bone and mineral metabolism. Besides the kidneys, other organs are also capable of making 1,25(OH)2-vitamin D, which exerts autocrine and paracrine effects. For these pleiotropic effects, a continuous vitamin D supply (daily supplements) with moderate doses is more effective than high-dose bolus applications. Beside the classical effects of 1,25(OH)2-vitamin D on the musculoskeletal system, there is good evidence for extraskeletal effects on the immune system. A good vitamin D supply can reduce the risk of respiratory infections. At the present time, the preventive and therapeutic use of vitamin D regarding COVID-19 (coronavirus disease 19) is of great interest. Springer Vienna 2021-03-17 2021 /pmc/articles/PMC7968561/ http://dx.doi.org/10.1007/s41970-021-00146-w Text en © Springer-Verlag GmbH Austria, ein Teil von Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Originalien Scharla, Stephan H. Pleiotrope Wirkung von Vitamin D mit Berücksichtigung von COVID-19 |
title | Pleiotrope Wirkung von Vitamin D mit Berücksichtigung von COVID-19 |
title_full | Pleiotrope Wirkung von Vitamin D mit Berücksichtigung von COVID-19 |
title_fullStr | Pleiotrope Wirkung von Vitamin D mit Berücksichtigung von COVID-19 |
title_full_unstemmed | Pleiotrope Wirkung von Vitamin D mit Berücksichtigung von COVID-19 |
title_short | Pleiotrope Wirkung von Vitamin D mit Berücksichtigung von COVID-19 |
title_sort | pleiotrope wirkung von vitamin d mit berücksichtigung von covid-19 |
topic | Originalien |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968561/ http://dx.doi.org/10.1007/s41970-021-00146-w |
work_keys_str_mv | AT scharlastephanh pleiotropewirkungvonvitamindmitberucksichtigungvoncovid19 |