Treatment of 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 inhibits TNF-alpha-mediated expression of MMP-9 protein and cell invasion through the suppression of JNK pathway and microRNA 221 in human pancreatic adenocarcinoma cancer cells

Human pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer type with a very high mortality rate. Inflammatory cytokine such as tumor necrosis factor- alpha (TNF-α) plays a pivotal role in the progression of PDAC. Recently, suppression of cell invasion by preventive agents has received consider...

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Detalles Bibliográficos
Autores principales: Cheng, Yen-Huang, Chiang, En-Pei Isabel, Syu, Jia-Ning, Chao, Che-Yi, Lin, Hung-Yu, Lin, Cheng-Chieh, Yang, Mei-Due, Tsai, Shu-Yao, Tang, Feng-Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968633/
https://www.ncbi.nlm.nih.gov/pubmed/33730072
http://dx.doi.org/10.1371/journal.pone.0247550

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