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Mycobacterium helveticum sp. nov., a novel slowly growing mycobacterial species associated with granulomatous lesions in adult swine
The occurrence of nontuberculous mycobacteria in different hosts and their implication as obligate or opportunistic pathogens remain mainly unclear. Mycobacteriosis in pigs is usually associated with members of the Mycobacterium avium complex and, in particular, with ‘ Mycobacterium avium subsp. hom...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Microbiology Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968739/ https://www.ncbi.nlm.nih.gov/pubmed/33355527 http://dx.doi.org/10.1099/ijsem.0.004615 |
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author | Ghielmetti, Giovanni Rosato, Giuliana Trovato, Alberto Friedel, Ute Kirchgaessner, Constanze Perroulaz, Carmen Pendl, Wolfgang Schulthess, Bettina Bloemberg, Guido V. Keller, Peter M. Stephan, Roger Tortoli, Enrico |
author_facet | Ghielmetti, Giovanni Rosato, Giuliana Trovato, Alberto Friedel, Ute Kirchgaessner, Constanze Perroulaz, Carmen Pendl, Wolfgang Schulthess, Bettina Bloemberg, Guido V. Keller, Peter M. Stephan, Roger Tortoli, Enrico |
author_sort | Ghielmetti, Giovanni |
collection | PubMed |
description | The occurrence of nontuberculous mycobacteria in different hosts and their implication as obligate or opportunistic pathogens remain mainly unclear. Mycobacteriosis in pigs is usually associated with members of the Mycobacterium avium complex and, in particular, with ‘ Mycobacterium avium subsp. hominissuis ’. Here we describe a novel slow-growing mycobacterial species isolated from lymph nodes obtained from two sows housed in different Swiss farms. The animals presented chronic inappetence and mild diarrhoea. Gross pathology revealed focal caseous lymphadenopathy of the mesenteric lymph nodes. Complete genome sequencing of the two isolates from the two sows was performed. The genomes comprised 5.76 Mb and an average nucleotide identity score of 99.97 %. Whole genome sequence, mycolic acid and matrix-assisted laser desorption ionization-time of flight mass spectrometry analyses revealed that the two isolates were not related to any previously described Mycobacterium species. The closest related species was Mycobacterium parmense , a slow-growing scotochromogenic mycobacterium first isolated from a cervical lymph node of a 3-year-old child. The name proposed for the new species is Mycobacterium helveticum sp. nov. and 16-83(T) (=DSM 109965(T)= LMG 2019-02457(T)) is the type strain. |
format | Online Article Text |
id | pubmed-7968739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Microbiology Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-79687392021-03-19 Mycobacterium helveticum sp. nov., a novel slowly growing mycobacterial species associated with granulomatous lesions in adult swine Ghielmetti, Giovanni Rosato, Giuliana Trovato, Alberto Friedel, Ute Kirchgaessner, Constanze Perroulaz, Carmen Pendl, Wolfgang Schulthess, Bettina Bloemberg, Guido V. Keller, Peter M. Stephan, Roger Tortoli, Enrico Int J Syst Evol Microbiol Taxonomic Description The occurrence of nontuberculous mycobacteria in different hosts and their implication as obligate or opportunistic pathogens remain mainly unclear. Mycobacteriosis in pigs is usually associated with members of the Mycobacterium avium complex and, in particular, with ‘ Mycobacterium avium subsp. hominissuis ’. Here we describe a novel slow-growing mycobacterial species isolated from lymph nodes obtained from two sows housed in different Swiss farms. The animals presented chronic inappetence and mild diarrhoea. Gross pathology revealed focal caseous lymphadenopathy of the mesenteric lymph nodes. Complete genome sequencing of the two isolates from the two sows was performed. The genomes comprised 5.76 Mb and an average nucleotide identity score of 99.97 %. Whole genome sequence, mycolic acid and matrix-assisted laser desorption ionization-time of flight mass spectrometry analyses revealed that the two isolates were not related to any previously described Mycobacterium species. The closest related species was Mycobacterium parmense , a slow-growing scotochromogenic mycobacterium first isolated from a cervical lymph node of a 3-year-old child. The name proposed for the new species is Mycobacterium helveticum sp. nov. and 16-83(T) (=DSM 109965(T)= LMG 2019-02457(T)) is the type strain. Microbiology Society 2021-01 2020-12-23 /pmc/articles/PMC7968739/ /pubmed/33355527 http://dx.doi.org/10.1099/ijsem.0.004615 Text en © 2021 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Taxonomic Description Ghielmetti, Giovanni Rosato, Giuliana Trovato, Alberto Friedel, Ute Kirchgaessner, Constanze Perroulaz, Carmen Pendl, Wolfgang Schulthess, Bettina Bloemberg, Guido V. Keller, Peter M. Stephan, Roger Tortoli, Enrico Mycobacterium helveticum sp. nov., a novel slowly growing mycobacterial species associated with granulomatous lesions in adult swine |
title |
Mycobacterium helveticum sp. nov., a novel slowly growing mycobacterial species associated with granulomatous lesions in adult swine |
title_full |
Mycobacterium helveticum sp. nov., a novel slowly growing mycobacterial species associated with granulomatous lesions in adult swine |
title_fullStr |
Mycobacterium helveticum sp. nov., a novel slowly growing mycobacterial species associated with granulomatous lesions in adult swine |
title_full_unstemmed |
Mycobacterium helveticum sp. nov., a novel slowly growing mycobacterial species associated with granulomatous lesions in adult swine |
title_short |
Mycobacterium helveticum sp. nov., a novel slowly growing mycobacterial species associated with granulomatous lesions in adult swine |
title_sort | mycobacterium helveticum sp. nov., a novel slowly growing mycobacterial species associated with granulomatous lesions in adult swine |
topic | Taxonomic Description |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968739/ https://www.ncbi.nlm.nih.gov/pubmed/33355527 http://dx.doi.org/10.1099/ijsem.0.004615 |
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