Fra-1 regulates its target genes via binding to remote enhancers without exerting major control on chromatin architecture in triple negative breast cancers

The ubiquitous family of dimeric transcription factors AP-1 is made up of Fos and Jun family proteins. It has long been thought to operate principally at gene promoters and how it controls transcription is still ill-understood. The Fos family protein Fra-1 is overexpressed in triple negative breast...

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Detalles Bibliográficos
Autores principales: Bejjani, Fabienne, Tolza, Claire, Boulanger, Mathias, Downes, Damien, Romero, Raphaël, Maqbool, Muhammad Ahmad, Zine El Aabidine, Amal, Andrau, Jean-Christophe, Lebre, Sophie, Brehelin, Laurent, Parrinello, Hughes, Rohmer, Marine, Kaoma, Tony, Vallar, Laurent, Hughes, Jim R, Zibara, Kazem, Lecellier, Charles-Henri, Piechaczyk, Marc, Jariel-Encontre, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968996/
https://www.ncbi.nlm.nih.gov/pubmed/33533919
http://dx.doi.org/10.1093/nar/gkab053

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