Structural basis for RNA recognition by the N-terminal tandem RRM domains of human RBM45

RBM45 is an RNA-binding protein involved in neural development, whose aggregation is associated with neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD). However, the mechanisms of RNA-binding and aggregation of RBM45 remain unelucidated....

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Detalles Bibliográficos
Autores principales: Chen, Xiaolei, Yang, Zhongmei, Wang, Wenfeng, Qian, Kaiyue, Liu, Mingjie, Wang, Junchao, Wang, Mingzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968997/
https://www.ncbi.nlm.nih.gov/pubmed/33577684
http://dx.doi.org/10.1093/nar/gkab075

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