The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence

Cells and organisms have a wide range of mechanisms to defend against infection by viruses and other mobile genetic elements (MGE). Type III CRISPR systems detect foreign RNA and typically generate cyclic oligoadenylate (cOA) second messengers that bind to ancillary proteins with CARF (CRISPR associ...

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Detalles Bibliográficos
Autores principales: Zhu, Wenlong, McQuarrie, Stuart, Grüschow, Sabine, McMahon, Stephen A, Graham, Shirley, Gloster, Tracey M, White, Malcolm F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969007/
https://www.ncbi.nlm.nih.gov/pubmed/33590098
http://dx.doi.org/10.1093/nar/gkab073

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