Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors

The paucity of recurrent mutations has hampered efforts to understand and treat neuroblastoma. Alternative splicing and splicing-dependent RNA-fusions represent mechanisms able to increase the gene product repertoire but their role in neuroblastoma remains largely unexplored. Here we investigate the...

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Detalles Bibliográficos
Autores principales: Shi, Yao, Yuan, Juan, Rraklli, Vilma, Maxymovitz, Eva, Cipullo, Miriam, Liu, Mingzhi, Li, Shuijie, Westerlund, Isabelle, Bedoya-Reina, Oscar C, Bullova, Petra, Rorbach, Joanna, Juhlin, C Christofer, Stenman, Adam, Larsson, Catharina, Kogner, Per, O’Sullivan, Maureen J, Schlisio, Susanne, Holmberg, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969022/
https://www.ncbi.nlm.nih.gov/pubmed/33555349
http://dx.doi.org/10.1093/nar/gkab054

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